135
Etiological851601012694140179249288358429467530599638
Factors1524601012686155218265334397450
of2010601012670116
COPD21626010126101210295396
Development25936010126101163233296335404483600660738785
Endogenous851844012886155226296366428498568638693
Factors1579844012878141201240310357411
Exogenous3244844012886155226296358428498568622
Factors3901844012878141203242311359412
Genetic85113320128101163233296335374437
factors13231332012846109170209278326379
Smoking,32441332012878188256327366436505541
exposure38201332012862132202272326396443506
to43611332012839108
tobacco45041332012839109179241304366435
smoke49751332012855164232303365
Congenital8511578012894164233304367436474514576614
alpha-117911578012862101171241302350421
antitrypsin25371578012862133171209249296366435490528599
deficiency8511819012870133180218280319381451514584
Occupational324418190128101163225296366428467506575646709747
hazards402618190128164226289350397466521
(inhalation458218190128140179249319381420482521560630700
of531718190128164211
dust,32442061012870141195233269
toxic35482061012838109179217280
gases38632061012870132186249303
in42012061012839108
the43452061012839108170
workplace)455020610128102171218288358396459521584631
Lung8512549012886155226296
malformations118225490128109169208256326373482542581621691762816
Environmental32442549012886155226265312382452561621691731794832
factors41112549012847109172209280327381
Severe8512795012878140211273320381
respiratory12672795012856119172243281329391429499546616
infections19162795012848119166229291330368439509563
suffered25142795012864134181228290336398468
in30182795012847117
childhood8513038012862133172211280351420490561
Pathogenesis8513663012686155203281351420483561622677715771
of16553663012671118
COPD:180836630126101210294395441
671406909146
Inflammation8514041012847117164202265374482543582622692762
of16494041012870116
the18004041012839108171
airways20064041012862100147249310381433
671431009146
Airflow85142820128101140187234273342444
limitation1330428201283977186223263325364404473543
and19094282012862132202
pulmonary21464282012870140179289357427490537607
hyperinflation27864282012870141209272319358429475513575615653723793
Expiratory8514657012886155226265312374412483530600
airflow14844657012863102148195233304406
limitation1924465701283977186223262325364403474544
is2503465701283893
the26314657012838108171
main283746570128109169208279
pathophysiological3151465701287113217124231138145252257561468472379386390296410261065
disorder42524657012873112167236283354415462
in47494657012839109
COPD.48934657012894195272374408
It5336465701284786
is851489801283994
based9794898012870133188249320
on13334898012870140
both15084898012870140179249
reversible17924898012847109178241287341381450489551
and23794898012862132201
irreversible2616489801283785131194263326372426465535574636
components.32864898012863133242310381451514583623677712
The8515273012886155218
irreversible1104527301283986133194265327373428466537575638
components17775273012862131241310380450513582621675
include:24885273012839108171209278349412450
671568409146
Fibrosis8515656012878117188234304358398452
and13385656012863131202
narrowing15745656012870133180226296397436505576
of21845656012870117
the23375656012839108171
airway25435656012862100147248310380
lumen;29575656012839109219280350390
671592609146
Loss8515897012886155210265
of11515897012870117
elastic13035897012862100163217256295357
recoil16955897012847109172241279319
of20485897012870117
the22005897012839108171
lungs24065897012838109178249303
due27435897012870141203
to29825897012837107
alveolar31245897012863102171234303342405452
destruction;36105897012870133186225272342405443481552621661
671616709146
Loss8516139012886155210265
of11516139012870117
alveolar13036139012862100170233303341404451
support17896139012853124193263333380419
for22436139012847116163
the24416139012838109171
lumen26496139012838107217277347
of30326139012870117
the31846139012839109171
small33906139012855164224263303
airways.37286139012863100148249311381434469
The8516515012886155218
reversible11046515012847109180241288343381451490553
causes16926515012861123193248310364
include:20906515012839110173211280351414452
671692409146
Accumulation85168960128101163225296405473513575615653724793
of16786896012870118
inflammatory18316896012839108155194256366474534573644691761
cells,26266896012862124164203258294
mucus,295468960128109177240310365401
and33906896012862131201
plasma36256896012871109172226336396
exudate40566896012863133203273336374436
in45276896012839109
the46716896012839109171
bronchi;48766896012870117188257320389428467
671716709146
Contraction8517139012894164233273320382444483521592661
of15467139012870118
the16997139012839108171
bronchial19047139012870117186257318389427490528
smooth24677139012855164232303342412
muscle;291471390128110177232295334397436
671740809146
Pulmonary8517380012878148188297365436499545616
hyperinflation.15007380012870140209272318358428474514576614654723794829