114
Dispensary10636010126101140195273336414467537600670
observation1767601012670149202265327396467513551621700
of2500601012671118
patients2653601012678147194233295373419474
with31616010126101141187265
chronic3461601012661139201272350388451
obstructive3945601012671149204251312390452499537608670
pulmonary4650601012678156195312380459529592661
disease.2962842012678117172234304358421456
Chronic8511215012894164211280351389452
obstructive13381215012877147202240287357419457497566629
pulmonary20021215012877148186296364434497544614
disease26501215012878117171234296350413
(COPD)30981215012854147248326427473
is36061215012848103
a37431215012870
heterogeneous38491215012877139177240287356426488557620689760814
lung46981215012851121191261
condition49941215012871140210280318358396466536
characterized8511456012862133195242305366405468513552615676747
by163314560128156227
chronic189314560128150221268338408447509
respiratory243714560128134197251321359407469507577625695
symptoms316514560128142213321389429499609661
(dyspnea,386214560128134204276328399470532594628
cough,452514560128149219290360430466
sputum502614560128141211281320390499
production)8511697012870117188257327390428467537607653
and15401697012895164235
exacerbations18101697012896165228289351398468531569607678748802
due264716970128104173236
to29181697012871142
abnormalities30951697012895165234305352462521560600638678741794
of392516970128102149
the41091697012872142205
airways43491697012894133179281343413466
(bronchitis,48501697012880150198268338400469509547587641675
bronchiolitis)8511938012870117188257320389428498537576615653708755
and/or164119380128152221291330400446
alveoli212219380128152191262324394432472
(emphysema),262919380128137199308376447517570633742803850885
which354919380128191261300363433
cause401819380128152214283338400
persistent,445219380128160222269324362416456518588626662
often514919380128159206244307376
progressive8512181012870117188257304367420474514583646
airflow30202181012862101149195233304406
limitation.4950218101283978188225264327366404474545580
Exacerbations8512422012886155218281343390459522559599669738793
and16792422012893163233
comorbid19472422012892161271339386456496565
conditions25482422012893162232302341380419488559613
are31972422012891138201
an34332422012893162
integral36302422012869140178241310357420458
part412324220128100163209247
of440624220128100147
the45882422012869139201
disease482424220128100139193256318372435
and52932422012893162231
contribute8512662012862133202242289327396467505568
significantly1454266201285593163233272319357420482551591629700
to21872662012839109
the23322662012839109172
clinical25392662012861100139210248311373411
presentation.29842662012870117180233295365405467506544614684720
A85130390128101
COPD9873039012894195272373
exacerbation13953039012862132195257320366437500538576647716
is2147303901283992
an22753039012862132
event24433039012862131194263302
characterized27813039012862131194240303364403466512551613676745
by35613039012870141
increased37353039012839109173219282343398460530
dyspnea43003039012870140194264334397459
and/or47943039012862131201240310357
cough51863039012863131201271340
with85132800128101140179249
sputum,113532800128113183254292362471504
worsening167432800128161231278332395464504573643
within235232800128160199238308346417
<14280432800128139209279
days,311832800128129191261314349
which350332800128159229268331401
may394032800128167227299
be427232800128129191
accompanied449832800128121183246316426494557627665728797
by533132800128128199
tachypnea8513521012839102164233304372443506568
and/or14543521012864134204243312359
tachycardia,18493521012841103165234304365427474544584646681
is2566352101283994
often26963521012871118157220289
associated30203521012864118173243305344406445508577
with363535210128101139178248
increased39193521012840110172219281344397460529
local44843521012841110173235273
and47933521012864134204
systemic50323521012857128180220283392428491
inflammation8513764012839110157195257367475535574613684755
caused16413764012874136205260323392
by20683764012883153
respiratory22553764012859121176247285332395433503551621
tract2909376401285299161224262
infection,32063764012852122169231294332371441510546
pollutants,37873764012883152191230300339401471510565600
or44223764012882129
other45863764012882122191254301
damage49223764012882144254314384447
to54043764012850120
the8514004012839110172
respiratory10594004012846107162231271317379418488535605
system.16984004012855125178217280389423