195
Pathogenesis:851601012686158206286358429494574637694735791841
The851839012886158222
portal1110839012884156205245310350
of1498839012883133
entry1668839012876147188237309
is2013839012852110
the2161839012853125189
mucous24018390128109179245316388444
membrane28978390128109171284354404469540604
of3538839012884133
the3708839012853125189
upper3935839012884156227291341
respiratory4313839012861124180252292342405446517567640
tract4988839012853103166231271
and5297839012876147219
the8511080012839111176
conjunctiva10631080012872143215257327399463505545617681
of17821080012878128
the19461080012848120184
eye.21671080012872144207245
Primary24491080012887135175287349398471
viral29551080012880121170234275
replication32671080012855120191232273338401441482554626
occurs39311080012878143206278327383
in43521080012847119
the45081080012848120184
epithelium47291080012872143184224296360402443514626
of53911080012878126
the8511321012839111176
respiratory10651321012873138194266306355419459531580652
tract17531321012867117181245285
and20751321012890163235
regional23481321012874138210250322394458498
lymph28841321012866139250320393
nodes.33151321012898169241307362399
This375113210128114186227283
is40721321012866122
followed42321321012876147188228300404467538
by48081321012899172
the50151321012868140204
first52561321012875115164220260
wave85115630128101165237302
of11901563012876125
viremia13521563012876116166230341380445
during18351563012876147198238310382
the22551563012845117181
incubation24731563012845117182253325389429470542614
period.31251563012875141188230302373410
The35721563012893163229
virus38371563012876117166237294
attaches41681563012868110151215279351415472
to46761563012845117
phagocytes,48311563012876148213284356420492532597653690
where85118050128101173237286350
it12381805012870111
replicates13871805012877141212253293359422462527583
and20081805012892163235
accumulates22811805012893158221293405475517581621686742
secondary30611805012884149213284356428493541613
to37101805012869142
the38901805012869141206
virus.41341805012899140190261317355
A452618050128132
new469518050128100165269
wave500118050128132196267331
of53701805012899148
viremia,8512046012870111160224336375440477
with136520460128130169210282
maximum168520460128138200272313424494607
virus23282046012898140190261317
concentration26832046012890161233298361433473523586628669740812
in35332046012866138
the37092046012866138203
blood,39502046012897138210282353391
corresponds43782046012890161211259323379451523595666723
to51392046012866138
the53152046012867139203
clinical8512287012862104144216257321386426
onset13152287012876148204268308
of16612287012876125
the18242287012844116180
disease.20422287012876116173238301357422458
The25372287012893163229
measles281022870128109171236292332398453
virus33002287012877118173245301
has36392287012876140196
a38722287012868
tropism3978228701284694165237278334446
for44592287012855128176
epithelial46722287012868140181222294358398439504544
cells52542287012868132172212269
and8512529012862134206
cells10942529012872135176216274
of14042529012879128
the15702529012847118183
central17902529012871135206247295360400
nervous22282529012878142191263335407463
system,27292529012862135190231296408443
as32092529012871128
well338325290128102166206247
as36682529012870126
vascular38322529012878143199263334375440488
endothelium,43572529012872143215287327399464505545617729764
which516725290128102174214278350
causes8512771012862127198255319376
damage12632771012885150261324396460
to17612771012853124
the19232771012853125189
skin21502771012868140182254
and24412771012877148220
mucous271427710128110180245316388444
membranes321027710128110172285355404469540605661
of39092771012884133
the40792771012853125190
respiratory43062771012861126181253294344407447519569641
tract,49832771012854102167230270308
the53282771012853125189
conjunctiva8513012012862134206247319391455495536608673
of156230120128188238
the183730120128157229293
eye,216830120128182254317355
and256030120128182253325
the292330120128158230294
development325430120128189254326390430502574686748821861
of415330120128190238
meningitis442830120128230292364405477549590631672729
and519430120128182254334
meningoencephalitis.85132540128109172244286358430502566637702765837909974101410551095113611921229
It211732540128101142
has229732540128122187243
an257832540128116187
immunosuppressive280332540128922043143844575295856577298018509149701026106711381204
effect404432540128116164213276341381
and446232540128116188260
reduces476032540128100164235307372436491
the52893254012893165229
activity8513495012862127167208280321361434
of132134950128132180
specific153934950128115187251316356405446510
and208534950128124195267
nonspecific239034950128131203275331403467532572620661726
protective315234950128131181252293357421462502574638
factors382834950128107172235275347397453
(anergy)431734950128109172244309357428501548
[10,490334950128108189261299
15].523834950128133205254291
Classification85137420126101142214270327367417457521592642682754834
(202417223742012649120192264336
Clinical209637420126102143183263304368440480
Guidelines261537420126109190230310374414455535599655
)32773736012847
[10,33613736012849121192230
15]36283736012871144194
By8513978012894166
Type:10553978012885157228293334
1.14293978012870107
Typical15733978012880143215255321392433
2.8514220012870108
Atypical:9984220012886125189261301367438479527
-8514461012847
Mitigated93744610128117157198238310382424488559
-8514702012847
Abortive9374702012886157229285326368432495
-8514944012847
Attenuated9374944012886126166231303375447487551623
-8515186012847
Asymptomatic9375186012886141206310381421493598668709750814
By8515427012894166
Severity:10555427012878142214279327367407480520
1.16155427012870108
Mild176254270128117157197269
2.8515668012870108
Moderate99856680128117188260324379451492557
3.8515910012870108
Severe9965910012871135200263319384
By8516152012894166
Course:10556152012893166238286342407447
1.15426152012870108
Smooth16866152012871175246317358430
2.8516393012870108
Rough:9986393012886157228300372421
-8516634012847
with9376634012894134175247
complications12226634012863134238309349390455527567608680752808
-8516877012847
with9376877012894134175247
superimposed12226877012855127199263318360463534606663727799
secondary20586877012856121184256328400471528593
infection26876877012840112154218281322363435507
-8517118012847
with9377118012894134175247
exacerbation12227118012863127199263327383455527568608680752
of20127118012871112
chronic21627118012863134190262334376440
diseases26397118012871112168232304361425481