168
Diagnosis8516010126101140210280359429483521576
67186709146
Epidemiological:8518410126941722112893514685065766156857557948569259651012
Contact1899839012894163232272334396435
with23698390128102140178248
a2652839012863
rubella2750839012846116186249287326388
patient.3173839012870132171210272342380416
671110809146
Clinical:85110820126101140179258296358429467514
Exanthema14011080012886155217287326396458567627
syndrome20651080012884155223294341410519579
in26791080012869140
the28541080012868138200
form30891080012877146192302
of342410800128100147
a36061080012892
fine-spotted37331080012875114184247297350421490529568630700
rash44681080012876139193263
not47661080012899169208
prone50091080012899147216285348
to53921080012868137
coalescence,8511321012862133195233296351412475544607669704
localized159013210128112181244307344383446507577
on220313210128143212
the245113210128110181244
extensor273013210128134204243305374429499545
surfaces,331013210128128198246291354416478532567
buttocks,391313210128142212251290359422491545581
and452913210128135205275
back;483913210128143205267337376
and525013210128135205274
lymphadenopathy85115630128391102182863574204905536226927628258639331004
syndrome188815630128108179249319366435545605
with252815630128155194233304
enlargement286715630128116185225287333403465575635705745
of364715630128124170
the38521563012893163226
occipital411315630128123185248287356395434497540
and468815630128116185256
posterior497915630128123194248286349396433504550
cervical8511805012862125171242280343405443
nodes.13301805012870139209272326362
671207709146
Laboratory:8512051012694164242311374444490561622693740
Serological6712290012678140203273311382452490553622661
method136822900126154214261339409488
(ELISA):18902290012683177271325404505551598
Detection252422870128101163202265326365404474544
in31022287012876147
the32842287012876146209
patient's352822870128107169207247309379417443498
blood406122870128106145215285355
serum44522287012891153200269378
of486422870128107154
specific50532287012892162225288325373411472
antibodies6712529012862133172211280351420459522576
belonging12832529012875137175245315385425494564
to18822529012844114
the20322529012843113176
immunoglobulin22432529012844154262330400471542580650720790829868938
class32162529012868107169224278
M.353525290128125160
IgM37302529012852121246
appears40152529012868137207270331378432
in44832529012843114
the46332529012843113175
first4843252901285392138193231
days51102529012874137207260
of54062529012875122
the6712771012839110172
disease,8772771012880118173235297352414449
reaches13612771012856118180243312375428
maximum183327710128109170240280390457568
levels24342771012848111181244283337
at28072771012871109
2–329522771012878150221
weeks,321827710128101163224294348384
and36372771012871140211
disappears38822771012879118173235305375436499545600
after45182771012870117156219264
1–248182771012879150220
months.508327710128109177247287357411446
Specific6713012012878148211273311358396459
IgG11653012012854123225
is14243012012845100
detected15593012012876139177240302340403473
2–320663012012877149219
days23203012012876139209262
later26173012012846109147210256
than29073012012846116179248
IgM,31903012012854123248283
increases35083012012844115177223286348402465518
to40623012012844115
a42113012012869
maximum432130120128109169240279390458569
by49223012012877148
the51033012012846117179
end53183012012869138208
of6713254012870117
the8233254012873142205
first10633254012880119166220259
month135732540128143210281320391
from17843254012879125195305
the21223254012872143205
onset236232540128104174229291329
of272732540128103150
the29123254012871142204
disease,315132540128103143197260322375438473
and36593254012896165235
persists393032540128102165212265304364403457
throughout44233254012872142189258329398468539608648
life.51063254012871111157219254
A539532540128135
fourfold6713495012847117188234281351389459
or11653495012871119
greater13193495012871118180243281343390
increase17443495012840110172218281343398460
in22393495012841110
IgG23853495012849118219
titer2639349501284079118180227
upon29013495012871141211281
simultaneous3217349501285695204272312351414483546615685740
testing39923495012840103157196234304374
of44013495012872119
paired45543495012872135173220283352
blood49413495012871109180250319
sera52963495012856118164226
(with6713737012847148187226296
an10023737012863132
interval11703737012839109148210257327389427
of16333737012870117
10-1417853737012870140188258328
days21493737012870132202256
from2440373701284894163273
the27463737012839110173
date29543737012870132171233
of32233737012870116
the33753737012839108171
first3581373701284886133186226
sample38413737012856118228295335398
collection)42733737012863133171211273335374412482553600
in49073737012840109
standard5052373701285493156226295358405474
serological6713978012855117164233273342412451514575614
tests13213978012837100155193247
is1604397801283992
grounds17323978012870117186257327396451
for22193978012847115162
diagnosing24153978012870110173242311382436475545615
rubella30653978012845116186248287326388
[1,34893978012846115154
14].36773978012871140187221
Molecular67142220126133202242304366444483552615
biological132042220126115154223262333402442503574612
method196842220126153214261339409488
(PCR):24894222012684170271371418464
Detection299042200128101163202265327365405474544
of356942200128106153
rubella37574220012883153223285323363425
virus421742200128106145192261315
RNA.456842200128130232332367
Used497042200128138192254324
for53314220012883153200
genotyping6714461012870133202273311382450490560630
the13374461012839109171
rubella15444461012846115185248287325387
pathogen.19664461012870133171242311382444514550