104
Pathogenesis851601012686155203281351420483561622677715771
The851839012886155218
portal1104839012870140187226288327
of1466839012894141
entry1642839012887156195242313
is198883901283994
the2117839012863133196
mucous23478390128134202265335406460
membrane28428390128134194305372420482552615
of3491839012895142
the3667839012863133196
upper3897839012894164234297344
respiratory4274839012872134188258297344406444515561631
tract.4939839012863111173235274310
The52838390128110180242
virus8511080012870110157226280
adsorbs11661080012863133187256304374428
onto16291080012871140178249
the19141080012837108169
epithelium21191080012862132171210279342380420489599
of27511080012870117
the29031080012839109172
mucosa,311010800128109178241310365428463
penetrates36061080012871133202265304351413452514568
into42091080012839109147218
the44611080012839109173
submucosa46691080012853123193303371433504559620
and53251080012862131200
regional8511321012847109179218289358421459
lymph13451321012850120229297367
nodes,17481321012882151222284337373
where216713210128101171234280342
primary25441321012881128166275335382453
replication30311321012858120191230270332394433471542611
occurs,36781321012880143204275322375411
clinically41241321012874111150221259322383422461532
manifesting470113210128109169239279326388443481521591660
as53971321012874127
lymphadenitis8511563012839110218286357420490553622661700739793
[10,16801563012846116187223
14].19361563012870141187221
The8511805012886155218
virus11041805012870110156226280
then14201805012839108171241
enters16971805012862131170232279333
the20661805012838108171
bloodstream22711805012870109179249319373413459521584693
—299818050128141
the31741805012838109172
viremia33811805012870110157218327364427
phase38431805012870140203258320
—419918050128140
with437418050128101140179249
fixation4658180501284786155218256295365436
in51291805012838108
cells52731805012862125162202256
of8512046012870117
the10032046012862132194
mononuclear123220460128132200271341412481544582645707754
phagocyte20212046012892162224294364427497534597
system26532046012877148201240303412
and30982046012884155225
in33592046012861131
the35252046012862132194
skin37542046012877147186256
epithelium40462046012884154193232302365403441512621
(the47002046012869108179242
virus49772046012892131178248302
has53152046012892154209
dermatotropic8512287012870133180289349388459498545614684723785
action).16712287012879141180219289359406440
A214622870128118
focal22982287012863134197259298
inflammatory26322287012855126172211274383491551590661708778
reaction34442287012864126188251290329399469
develops,39482287012887150219281319390460514549
with453222870128118156196266
components48342287012878148257325396466529598637691
of8512529012870117
immune10032529012840149257325395458
inflammation,14962529012839110157195258367475535574614685755791
leading23222529012838101162232271341411
to27692529012837108
the29122529012838108170
appearance31172529012863133202265327374436506568629
of37822529012870117
a39342529012862
rash40312529012847109163232
[14].42992529012846119188236269
1-28512771012870118188
days10732771012897159229282
after13912771012889136175237284
the17102771012865136197
rash19422771012874137190261
appears,22372771012890159230292354400455491
viremia27612771012897136183245355391454
ends,32502771012888159228283319
and36042771012888158228
virus-neutralizing386727710128961351822523063584274905595986447077467848478869561025
antibodies49282771012889158197236306377446485547601
appear8513012012862133202265327374
in12603012012838109
the14043012012838108171
blood.16093012012870108179249318354