155
Source851599012678148227289351413
of1299599012670117
infection:1451599012638116163225288334372442521567
a2054596012861
sick215059601285594157226
person.2410596012870133180233304373409
Transmission851844012694156226305358475513568623661731809
routes:1696844012662132209256318373419
Contact8511080012894164233273336397436
(household13221080012847116186256310373442513551622
items)1979108001283877139249302349
Airborne85113210128101140187257327374443506
(nasal13921321012847117178233296334
secretions17611321012855116179225288326365435506560
and23561321012862131202
saliva)25931321012853116154194263326373
[12].30011321012847118187235269
The8511563012886155218
virus11041563012877117163233287
is14271563012846100
most157015630128109177232272
active18771563012871133171210280343
222551563012876
days23671563012876139209262
before26651563012877140186255303365
the30651563012846116178
onset32771563012877148203265304
of36161563012877123
symptoms37741563012862132241309348419529581
and43901563012869141211
546371563012876
days47481563012877140210263
after50471563012869115154217264
the53521563012846116179
onset8511805012870141195258296
of11821805012870117
clinical13341805012862100139209248311373411
symptoms.17801805012855125234303343412522574610
Human85120460128101171281341411
susceptibility12972046012861131186248310380419457528567605644683754
to20852046012845115
this22362046012843113152206
virus24782046012875114161230284
is2798204601284498
universal;29322046012875145184253316362416479517556
it3524204601284383
affects36412046012868115162224286324379
previously40552046012876122184255293363433488526597
uninfected46852046012876146185255303364426465527597
and53182046012867137206
unvaccinated8512287012870141210273336397436505568606669738
patients.162422870128130193232270333402442496531
In219022870128108177
vaccinated240222870128130193255317355425488527589659
individuals,309522870128100170240279349388458527590628683719
the38492287012898168230
disease411422870128130170224287348401464
is46132287012899154
milder480122870128170207247317380427
and526222870128123193263
complications8512529012862133242310350389452514552590661731786
are167225290128121167229
virtually193625290128129167214253323386424463534
nonexistent.250325290128129199269332401440494534595666704740
After327925290128160206245308355
mumps,366925290128168236346414469505
lifelong42092529012897137184246284355424494
immunity47382529012898207315383454493533603
is53752529012897152
maintained85127710128109170209280319381420490553622
[12,13].15082771012847117187223293363410444
Pathogenesis8513258012686155203281351420483561622677715771
The8513495012886155218
mumps110434950128137205315383438
virus15783495012897136183252307
enters19193495012890159197260307360
the23153495012865136198
body25473495012898167237308
through28883495012866137184253322393463
the33863495012865136198
mucous361934950128136204267337408462
membrane411634950128137197307375422484554617
of47673495012898145
the49463495012866136198
upper51783495012898167237300346
respiratory8513737012847109164233273320381420490537607
tract1492373701284289151214253
and17793737012866136206
conjunctiva,20203737012865135205244314384446485524594656691
multiplies274937370128109177217256295365404443505559
in33443737012841112
the34913737012841111174
epithelial37003737012865134174212282345384422485523
cells42583737012866128166206260
of45533737012872120
the47083737012842112179
respiratory49223737012849111166236274321384422492539610
tract,851397801283986149211249284
and11713978012873142213
spreads14183978012866136183245307377431
hematogenously18853978012880143251312351422493554625694764819857928
to28463978012851121
all30033978012873112150
organs31893978012880127198259330384
and36083978012873143213
tissues.3856397801285089143197268331384420
The43113978012897165228
most458639780128109177232271
susceptible48923978012866135190252315384423462531571632
are8514220012862109171
the10584220012839108171
salivary12644220012855116155194264326373443
glands,17404220012870110173243312366402
genital21774220012870132202241279342380
glands,25934220012870108171240311365400
pancreas,30284220012870132202264310373435490525
and35894220012861130200
the38254220012839108171
central40314220012862124193233279341380
nervous44454220012871133180249320389443
system.49244220012855125178217280389422
The8514461012886155218
viremic11044461012870109156218327364427
phase15664461012870140203257320
lasts19214461012837100155193248
522034461012871
days.23094461012870133203256292
The8514702012886155218
acute11044702012878140209248310
period14504702012884147193231301371
is18564702012854108
characterized20004702012877146209256318381419481528566629691760
by27964702012884154
the29844702012854124186
development32054702012885146217279321391461571631701740
of39814702012884131
edema41474702012878147210319379
and45614702012877148217
lymphocytic48134702012854125233301372442505575613652715
infiltration8514945012839110157195233273320381420459529599
of148549450128117164
the16844945012886155218
interstitial19374945012886155195257303358396436474513575614
space258649450128102172235297358
of297949450128117164
glandular317849450128117156219288358428467530576
tissue37884945012887125180234304367
with419049450128149186226295
damage452149450128116179288348418481
to50374945012887157
both522949450128117187226295
glandular8515186012870110172241311382420483530
and14165186012862131201
connective16525186012863133202272335397435474544607
tissue.2294518601283977131186256318354