295
Clinical8516010126101140179258296358429467
Manifestations13536010126133202280319366428482529598645683753831886
The851839012886155218
incubation1104839012862131194263333396435473543613
period1753839012891154201239308378
is2167839012861115
3-142317839012892141210281
days.2633839012892154225277313
There29818390128108178240287348
is3364839012862116
a3515839012885
gradual3635839012892139201270341403442
onset4112839012892161216279317
with44648390128123161201271
normal4770839012893162209319379418
body5223839012893162233304
temperature,8511080012839102211279342388451490559607669704
absence159010800128100169224287356419481
of210510800128108156
intoxication22961080012877146185256325364426489527566636706
symptoms,30381080012891162269337377447558610646
and371910800128100170241
the39951080012876146209
appearance423910800128100169239302364411473542605666
of494010800128109156
a51311080012899
dry,526510800128108155226259
persistent8511321012870133180233273327366428498537
cough14231321012862131202272341
that18001321012839108171210
progressively20441321012870117187257304366420474513583646684754
worsens.283213210128101173220275337408462497
The8511565012694172234
peak112015650126125187257336
period148815650126125187249288359437
of196015650126116162
the21571565012693171234
disease242615650126124163217280349404467
is2930156301283893
characterized305815630128108178240285348410449512558597659721791
by388415630128116186
paroxysmal,410415630128116179226296366435488599659698734
convulsive487315630128108178249320389428483521592654
coughing,8511805012862133202273342382452521557
a14431805012866
whooping154918050128101169240310379419488558
inhalation21431805012842112182245283345385423493563
through27411805012843113160229300369439
a32151805012866
spasmed33161805012859129192245355415485
glottis38361805012875114184224262301356
(reprise),4227180501285097159228276315369431478513
and47751805012866136205
vomiting50161805012873143253289329368439508
after8512046012862109148211258
coughing11442046012862131201271341380450520
or16992046012870116
the18512046012839108171
expectoration20572046012861131201263326364434481543582620691760
of28512046012870118
viscous,30042046012870108163225294365419454
glassy34932046012870108171225280350
sputum.38772046012854124195234304413446
Classification85122920126101140210265320358405444506576622661731810
by16962292012678147
Severity18792292012678139208271333371418488
Mild85125310126133171210289
severity:11752531012663125194257319357405475521
The17322529012886155218
number19852529012878148258326388435
of24552529012880127
convulsive26172529012872141211281351390444483553616
cough32682529012870141210281350
attacks36542529012871109149212273343397
per40872529012878140187
day43092529012879141210
is45532529012848103
8-10,46912529012880131202271307
and50332529012871140211
they52792529012847118180250
are8512771012862109171
brief.10582771012872119157220266302
The13962771012886156219
patient's16502771012871134171211273343381407460
condition21462771012864134204274313352391461530
is2712277101284195
satisfactory,28422771012857120158196251298360422460530578648681
general35582771012872135205268314376415
well-being401127710128101163201240291361424462531602
is4648277101284095
not47792771012871140180
impaired,49942771012840150217280319366429499535
and8513012012862133202
appetite10893012012862132202264302342380443
and15673012012862131202
sleep1804301201285393155217286
are21263012012862109171
preserved.23303012012871118180234296343412475545581
There29453012012886156218264326
are33063012012862109171
no35123012012870140
complications36873012012862133242310349388451513551590660731785
[8].45073012012847121168202
Moderate85132560126133202281343405474522584
severity:14703256012655117187250312351398467514
Convulsive20193254012894164233304374413467506576639
cough26933254012863132202273342
attacks30713254012863102140202264335389
occur34953254012871134196265313
up38433254012871140
to40193254012840109
15-2041643254012871140191260329
times4529325401284079189249303
per48683254012871134180
day,50833254012871133203237
are53553254012863109172
prolonged8513495012870117188226296366436499568
and14543495012875144215
pronounced.17053495012881129198267338407478540602672708
At246134950128101138
the26353495012852121184
end28543495012875144214
of31033495012883131
an32683495012875145
attack,34493495012875113152215276346382
the38663495012850121183
expectoration40843495012875145215277339377447494556595633704773
of48933495012882129
viscous,50573495012882121175238307378432467
thick8513737012839110148211280
mucus,118437370128109177240310365401
sputum,16203737012872141211250320430464
or21193737012887134
vomiting22883737012888158267304344383453523
is28473737012855110
observed.29933737012886156211274319390453522557
The358537370128103173236
patient's38563737012886149188227289359397423477
general43693737012886148218281328390429
condition48333737012880149219289328367406475546
is54143737012856110
disturbed.8513978012870110164203273320389452521556
Complications,14423978012894164273341381420482544583622691762816852
both23283978012870140179249
specific26133978012854125188249288335373436
and30843978012862131201
non-specific,33193978012871141211259312383446507546593631694729
often40823978012871117156219288
arise.44053978012862108147202264299
Severe8514222012678140211273336397
severity:12834222012684147216279341379426495543
The18624220012886155218
number211442200128100171280348411458
of260742200128100147
convulsive27894220012892162232301372410464504573636
cough34604220012892162232302372
attacks38684220012892130168231293362417
per43214220012899161207
day456342200128100163233
is48294220012869124
25-30498842200128100171221292361
or538542200128100146
more.85144610128109177224287322
The12124461012886155218
attacks14654461012867106144207270339394
are18934461012867114176
severe,21034461012859122191254300363398
prolonged,25364461012873120189229299368439501571606
and31784461012865134204
end34174461012867137206
with366344610128102139178248
vomiting.39474461012873143252289328368438508543
Pronounced45254461012882129199268339409478541603673
signs5233446101285897167237292
of8514702012870117
oxygen10034702012897167238306369438
deficiency14774702012896159205243306345407477539608
are21184702012890136199
noted.23524702012897168206269338374
Sleep276147020128105143205268337
and31334702012890159229
appetite33974702012889158229292330368408470
are39014702012890137199
severely41344702012882143214277327390429499
disturbed.46674702012897136191230300347416479548583
The528547020128113183244
occurrence8514945012870133195264312358421490553615
of15014945012881128
life-threatening1664494501285190136199247285355402464526565628697736806876
complications25754945012874144254322361401463525564602672742797
is34074945012851105
characteristic35474945012874144206253315378416478525563618657695758
(respiratory43404945012858105166221292330377440478547594665
arrest50384945012874121167230284324
or53984945012881129
repeated8515186012847109179242305342405474
apnea,13615186012868138208270332367
cerebrovascular17635186012867130177239309356426496559613676745783846893
accidents26915186012868130193231300363432472526
in32525186012845114
the34025186012845114177
form36145186012852123170279
of39265186012876123
intracranial40845186012845115154201263326372435504543606644
hemorrhages,47645186012875137246314361408478541611673728762
convulsions8515427012862133202273342382436474545615669
against15555427012863133195233303358396
the19875427012839108171
background21935427012870132194264334381450520591660
of28895427012870116
hypoxic30405427012870140209280350389452
brain35255427012871118180218289
edema)38495427012862131194303363410
[8].42945427012847120167201
Diagnostics85156680128101140203273343412467506545608661
Laboratory8515911012886148218289336397436506553623
Diagnostics150759110128102140203273344413467507545607662
671618009146
Detection85161520128101163202265327365405474545
of143161520128134181
DNA164761520128166267367
of204961520128135182
pertussis226661520128134197244283353407462500554
pathogens285661520128134197236306375445508577632
(Bordetella352361520128111205274321391453492555593631694
pertussis,425261520128135198243282353407461500554590
Bordetella487761520128158228275344407445508547585648
parapertussis,8516393012870133180242311374421459528583637677731766
Bordetella16596393012894164211280343381443482521583
bronchiseptica):22776393012877124193264326396434489551621660698761823870908
A322163930128102
single33576393012862101172241280343
examination37356393012869139201310347417480519559628698
of44686393012876124
mucus463563930128109177240310364
from50346393012854101171281
the53476393012846117179
posterior8516635012870141195233296343382452499
pharyngeal13856635012878149211257327396466529591629
wall205966350128101163202242
or23366635012879126
nasopharynx24976635012879142195266336405468515585654724
(throat3257663501285594164210281343381
swab)36746635012864165227296343
using40536635012879133172242312
a44006635012872
molecular451666350128109177217279342418456519566
genetic51176635012878141211273312350413
method85168770128109170209280351420
–13066877012870
polymerase14126877012870139179249358418465527582644
chain20906877012863133195234304
reaction24306877012846109170232271310379450
(PCR).29156877012847125217311358391
671714609146
Enzyme-linked8517118012886155218288397457504543582653724785856
immunosorbent17427118012840150258325397468522592639709771841880
assay26577118012864119173236306
(ELISA):29967118012849135220266345447493532
Detects356671180128101163202265327365419
antibodies40217118012864134173212282351422460522577
of46337118012873120
the47887118012840110172
IgM,49957118012849119245280
IgA53107118012848117219
(in851735901284786156
the10427359012843113176
early12537359012867128174214284
stages)1571735901285998160230293346394
and20007359012865134205
IgG22407359012850121223
(in2497735901285189159
the26917359012844113176
late29027359012842105143206
stages3143735901285897159229292346
of35247359012875121
the36807359012843113176
disease)38917359012873112167229291345408454
classes43807359012867105167222276339392
in48087359012842113
the49567359012842112175
blood.51667359012873113182252323358
When85176000128133201264334
IgG12217600012851121223
antibody14787600012867137176215285355425496
titers2007760001284383122185231285
are23287600012867113176
detected25397600012873136174237299337403472
in30467600012844114
individuals31967600012842112182221291330400470532571625
vaccinated38577600012874137198261300369432470533602
within449876000128101139179249288358
the48917600012843113176
last51027600012843106160199
5-753377600012873124193