99
Pathogenesis851601012686155203281351420483561622677715771
The851839012886155218
pertussis1104839012885147193232302357411449504
bacillus1644839012883145208246285324393447
enters2127839012876146185247294348
the2510839012852123185
mucous27458390128109177239310379434
membrane32288390128109170280348395458528591
of3854839012884131
the4020839012852122184
upper4240839012883153223286332
respiratory4607839012861124177247286333395434503550621
tract5261839012853100162225263
and8511080012862133202
colonizes10891080012864133173242313351414476530
the16541080012840111172
ciliated18621080012864102141180242281343412
epithelium23101080012864133173211281344383421491600
lining2943108001284181151191260330
the33081080012841111174
larynx35171080012840103149220288359
and39101080012864135209
bronchi.41541080012871118187258320390430465
The46561080012886154217
bacteria49081080012871134196234297344381444
do53871080012871141
not8511321012870141179
penetrate10661321012888150219282320367430467530
into16311321012857127165236
deep19021321012887150211281
tissues2219132101285695150204274336391
and26461321012879149218
do29001321012887157
not30931321012887157195
spread33241321012872142189251314383
throughout37421321012857127174243313383454523593632
the44101321012855125188
body.46331321012888157227298331
Bacterial499913210128111173236275338384423486524
toxins8511563012839110179219288342
provoke12291563012870117186256327396459
a17231563012862
local18201563012838108170233270
inflammatory21261563012839108155194256365474535574644691762
reaction.29211563012847109171234273312382453488
After85118050128101148187249296
the11821805012858129190
bacteria14081805012889151214252314361400462
die,19051805012889128190225
endotoxin21651805012882153222292331401472510580
is27801805012858113
released,29291805012865128167228291344407477513
which347518050128122191230293363
causes38721805012883145214269331385
the42931805012858128189
spasmodic45171805012875145207261371438509549611
cough51631805012883152222292362
characteristic8512046012862133195242305366405468513552606646684747
of16322046012882129
pertussis.17952046012882143190229300355409449503538
As238020460128101154
the25692046012851120183
disease27862046012882120174237299353416
progresses,32372046012880128198267315377430484547602637
the39082046012851120183
cough41262046012873143213282352
acquires45132046012874137206275315362423478
a50252046012874
central51342046012874136206244291354392
genesis8512287012870133202265319358412
–129822870128102
a14362287012894
focus15652287012878148210280334
of193522870128101147
excitation21172287012894164226265304366404444513584
forms27362287012878147195304356
in31282287012871140
the33042287012870140203
respiratory35412287012879141195265304351413451521568638
center42122287012895157227267330375
of462222870128101149
the48062287012869140202
medulla504322870128141201271342382420483
oblongata.8512529012870141179249320389452490553588
The147425290128116186247
cough17572529012893162233302372
occurs216425290128100163225294341396
reflexively25952529012877139186224287356396465528566636
in32662529012870140
response34412529012877140193264334403458521
to39962529012870139
various417125290128100162209247317387441
stimuli46482529012884124162272340379419
(touch,51022529012878115185256318388423
pain,8512771012870133172242277
laughter,11632771012839100171240310349412458493
conversation,16912771012862132202272334381434497536575644715750
etc.)24762771012862100163198245
[7].27572771012847116163197