186
Pertussis.851601012686148210257335389443483537572
Definition8518440126101163210249328367413452521600
of1486844012670116
the1637844012647125187
Concept18598440126101171248310373451498
Pertussis8511080012878140187226296351405444498
(Pertussis)13851080012849126188235274343397452491546592
is2012108001284195
an21431080012864133
acute23121080012864126195235297
anthroponotic26441080012864133173242289358429499568638677716779
infectious34581080012840110156219281319359428498553
disease40471080012870109164227288343404
caused44861080012865127197251314383
by49051080012871141
bacteria50801080012872134197236298344383445
of8511321012870117
the10031321012868138200
genus12381321012899162232302356
Bordetella,162913210128123192239309371410472511551612647
primarily23121321012899145184294354401440479550
Bordetella289513210128123194241310372411474511551614
pertussis,35431321012899161208247317371426464519555
transmitted41331321012867114176246300409446485525588658
by482513210128100171
airborne50291321012892131178247317364434496
droplets,8511563012870117188257296358396451487
characterized13731563012871140203250312373413475521560623684753
by21611563012880150
a23451563012871
prolonged24511563012880127196235305375445507577
paroxysmal30641563012878141188257327398451560620659
convulsive37591563012871142212282352391445485554617
(spasmodic)44111563012856110180243297406474545584647692
cough,51391563012871140211280350386
and8511805012862133202
damage10891805012870132241302372435
to15591805012839109
the17031805012839108171
respiratory,19091805012847109163232272319380419489536606640
cardiovascular,25841805012861124171241280350421482537600669707769816851
and34701805012862132202
nervous37071805012871133180249319389443
systems41861805012855125178217280388440
[6].46621805012847119167202
Etiology8512051012694140179249289358429498
The8512287012886155218
causative11042287012880143212266329368406476538
agent16782287012880149211280319
of20322287012887134
pertussis22012287012887150197234305359413453507
(Bordetella27432287012864157227274343406444507545584647
pertussis)34242287012888149196235305359414452508554
is40132287012856110
the41592287012855125188
pertussis43822287012887148195234304359413452506
bacillus,49242287012886149212249288327397452488
a54452287012880
gram-negative,8512529012870117180289334404467537600638677747809844
aerobic,173125290128172234280349419458520556
non-motile232225290128178249319368477545584624662725
bacterium.308225290128179242304342405451489560670702
Other381925290128211250321383430
Bordetella428425290128204274321390453492554593631694
species501325290128164234297358397460514
(Bordetella8512771012847140211258327390428490529568631
parapertussis,15172771012890152198261330393440477548602657696751786
rarely23382771012867131178239278348
Bordetella272027710128113183231301364402464502542604
bronchiseptica)33592771012890137207277340409448502565634674712775837883
cause42772771012882144214269331
a46432771012883
pertussis-like47612771012889152198238307361416455509560599637708770
illness851301201283978117188249304358
(clinical12453012012846109146186255295357419458
pertussis).17373012012870133180218287341396435490536571
The8513254012886155218
first1104325401284988134189227
serotype13673254012856118165235274344413476
is1878325401284195
detected20083254012871134173235297336398468
in25123254012839109
patients26573254012872133173211274343382436
with313132540128101138178247
severe34143254012857118189250297359
and38093254012864133204
moderate404932540128109177248311357420459522
forms,46063254012848118165274326362
while500432540128102171211250312
the53513254012841111174
second8513495012855117180249319389
and12763495012862131201
third15133495012837108146194263
are18113495012863109172
detected20163495012870133172234296335397467
in25193495012837108
patients26613495012870133171210272342381436
with313234950128102139178248
mild341534950128109146185256
and37063495012863133202
atypical39443495012862100170239278341403441
forms44213495012846117163273325
of47823495012870117
pertussis.49343495012870133180217287342396436490525
The8513737012886155218
pertussis11043737012870133180218287342396436490
bacillus16283737012870133195233273311382436
produces20983737012871117187258327390452506
exotoxins:26393737012862133202240311381419490544583
671400709146
Pertussis8513978012878140187226296351405444498
toxin13853978012855125195234304
(lymphocytosis-stimulating17253978012847861562653334034745366066437147698078629119641003104211521219125913221361139914691539
or32993978012887134
histamine-sensitizing346839780128871261802192813904274985606096647277968508899289671029106811391208
factor),47123978012863125188226295343389424
which517139780128118188227289358
is851422001283994
of9814220012880127
primary11434220012882129167277337384455
importance16314220012851162230300347386448518581644
in23104220012849120
pathogenesis24654220012881144183252322393455525586641680735
and32344220012874144215
has34844220012881144198
systemic37184220012865136189228291400437499
effects42524220012874121168230293332386
(hematological46734220012859129192301361400471509580650688751813851
and8514461012862133202
immunosuppressive)10894461012810221232038745852958465472479484190395710111050112011821229
-235244610128113
it250044610128103142
causes267744610128126189258312375429
the314144610128102172234
development341044610128134197266328366437507616676746788
of423444610128133180
the444844610128103173236
characteristic471944610128125196257304366429467530576614669708747809
convulsive8514702012862133202273342382436474545608
(spasmodic)14944702012847100169232286395463534573635682
cough.22114702012862132202273342378
671497309146
Tracheal8514945012886132194257327390452490
cytotoxin13774945012862132169240278349418458527
(damages19414945012847116177288348418481535
the25124945012838108171
epithelium27184945012862131170209279342379419489597
of33494945012870117
respiratory35014945012847109164235273320383420490537607
tract4142494501283986148210250
cells).44274945012861123162201256303338
671521409146
Dermonecrotic85151860128101163210320388459521584631700739778840
toxin17275186012837108177216287
(possesses20505186012846116187241295357412466529582
vasoconstrictor26685186012870132186256319388458512551598636699738807854
activity).35585186012862124162201271310349420465500
671545509146
Lipopolysaccharide851542701288612419526533540544351456762969275482488793497210421104
(possesses19925427012846115186240294357411465528581
endotoxin26095427012862133202272311381450490559
properties).32025427012871118188258320367405443506561607642
The8515668012886155218
bacterium11045668012870133195233296343382452561
is1698566801284095
unstable18285668012870141196235297367406468
in23315668012839109
the24765668012839109171
external26825668012864133171234281350413452
environment31685668012863132203241288358428538598668708
and39115668012862133202
quickly41495668012870140179241311350421
dies46045668012870109171226
when486656680128101170233302
dried,52035668012870117156219289324
exposed8515911012862133202273327390459
to13455911012839108
ultraviolet14895911012870108148194256327365435474537575
radiation,20985911012847110180219281320358429499534
or26675911012870116
under28185911012870140210272319
the31725911012839108170
influence33775911012839109157195265327396459522
of39345911012870116
disinfectants40855911012870108163202271319381442481544613652706
[6,7].48275911012847120155224272306