114
Diagnosis8516010126101140210280359429483521576
[1,1463601012646115151
3]:1648601012671118164
1.671839012870106
Clinical851839012894133172242280343405443
and13308390128131200270
Epidemiological:163683901281552242633323955035406106507217918308929559931031
Acute27048390128101163233272335
onset,30748390128138208263325363399
characteristic35088390128130200263309371433471534581619674712752813
dense43578390128138200270325387
membranes,47788390128179239349417464526597660714750
swelling8511080012855156218257296335405474
of13611080012870117
the15131080012838109170
neck17181080012871133196265
soft20181080012853123170209
tissues,2263108001283777131185255318372407
epidemiological27051080012862131170240303412449519559628699738800863901
history.36411080012870108162202272319389422
2.6711321012870106
Laboratory:8511321012886148218289336397436506553623660
o671159908060
Bacteriological8511563012894156218257320366405475514584653693755817856
method175915630128109169208279348419
(Gold22141563012863164233272342
standard):25911563012871110173242312374421491537576
Collection32031563012894164204242305367405444514584
of38221563012887134
swabs39911563012870172234304358
from43851563012861108178288
the47081563012855126189
throat49321563012855126172242305343
and53101563012879148219
nose8511805012870141195258
(fromunder1144180501289213818525436415411805012870141211274328
the19051805012839108171
membrane!)211018050128156216326394441503574636683730
with287518050128147185225294
culture320518050128106176216254324371434
on367418050128115185
selective389418050128100162201264325364402473535
media446318050128155215285325388
(Clauberg,48861805012892186225287356426489536605640
Tyndall).8512046012886156225295358396436483518
Isolation14042046012860114185223286324363433502
ofC.1942204601288413121092046012894129
diphtheriae22732046012884123193263302372434489527598660
and29692046012862132202
mandatory321920460128110171241312374412483530600
determination38522046012884146186248294403440510573612652721792
of46802046012883131
toxigenicity48452046012853122192231301364433472534573612682
(gel8512287012847117180218
precipitation11042287012870117180241280350388428490528568637707
test,18472287012839101155193229
PCR21102287012878172266
for24112287012846116164
the26102287012839108171
tox28162287012839110171
gene).30222287012870133202265310346
o671256508060
Serological8512529012878140187257296366436475537600638
method:152425290128141201240311382451491
RPHA,20502529012894172273374408
ELISA249325290128118203249327429
for29562529012879149196
the31882529012871141204
detection342725290128101164202264327365404474544
of400625290128102149
antitoxic41892529012895165203242281351421460523
antibodies47472529012893163202241311380451489552606
in53882529012870140
paired8512771012870133172218281351
sera12372771012853116163225
(retrospective).1497277101284793155194240310364435497559597637706769816851
o671304908060
PCR:8513012012878172265304
Rapid11913012012893156225263334
detection15593012012870133172233296335373443514
of21073012012870117
the22593012012839109172
toxin24663012012839108178217287
gene27883012012871132202265
in30883012012838107
the32313012012839108171
swab.34373012012855156218287323
o671329008060
Complete8513254012894164273341381444483545
blood14303254012870110179249320
count:17853254012862131201271310349
Moderate217132540128125194264326373436474536
leukocytosis,27423254012839101171241310373443481551606645700735
neutrophilia,35113254012870133202241288357427498536575614677712
elevated42583254012862100162232294333395465
ESR.47593254012886163257292
Important:8513495012847157225296343382444514552592
Treatment14793495012885132194255294404464534574
with208734950128120159198269
specific23913495012874143206268306354391454
antitoxin28803495012881152190229268338407447516
should34323495012873143214283322392
be38603495012888150
started40453495012874112175222260326396
immediately44763495012858169277337407447509548611649720
upon52293495012889159230300
suspicion8513737012855125179249288351389459529
of14143737012870118
diphtheria,15673737012870108178248287357419466505567602
without220337370128102140180250320390429
waiting266837370128101162200240278348419
for31223737012847116163
laboratory33193737012839101171242288351389459506576
results.39283737012847110164234274313367402