211
Diphtheria12056010126101140218296343421484546584654
Definition.12058440126101163210249328367413452521600635
Diphtheria120510820126101140218296343421484546584654
is1896108001284196
an20281080012865134
acute21981080012866128198237299
anthroponotic25321080012865135174243291361430500571640679718781
bacterial33491080012872135197235297344383446484
infection38681080012842112159222284322361431501
caused44041080012866128198252315384
by48221080012873144
toxigenic50001080012842113184223293356425464527
strains851132101285594141202241311366
of125313210128137184
Corynebacterium,14721321012816123027834841647954961167371277582286093010391074
characterized258113210128130200263310372435474537583621683745816
by343213210128137208
inflammation367313210128107178225264326435543604643683753823
of453113210128139185
the475113210128107176239
mucous502513210128177245308378448502
membranes85115630128109170281348396458528591646
or15321563012899146
skin17131563012884154194263
with201215630128129168207277
the23241563012869139202
formation25611563012876146194303363402441511581
of31781563012899146
fibrinous33591563012876115185232270341410480535
films39291563012877115154264316
and42811563012892162232
signs45491563012883122192262317
of49011563012899146
general508215630128100163232295341404442
intoxication,8511805012839110148219288327390452490529599669704
as159018050128117171
well179618050128156218256294
as212618050128117170
severe233218050128108171240303349412
damage277818050128125187296356426489
to33021805012894163
the35011805012892163225
cardiovascular,376118050128117179226295334404474537590653722761823870905
nervous,470118050128124187233302372443497532
and526818050128117186256
excretory8512046012862133195242305343412459530
systems14142046012855125178217280390443
due18922046012870141203
to21302046012839109
the22752046012837108170
action24802046012862124163202271342
of28562046012870117
a30082046012863
specific31062046012854124185248287334372435
exotoxin35762046012862131202240310380419489
[1,41042046012847116151
2].42902046012870117151
Etiology.12052292012694140179249289358429498534
Characteristics177322920126102179250311381444490552615653707754793855909
of27162292012671118
the28692292012647125187
pathogen.30912292012678147194272341411474551585
Diphtheria120525290128101140210280320389452499537599
is18392529012855109
caused19832529012878140210264327396
by24152529012885156
toxigenic26042529012854125196235305367436476538
strains31772529012870109155218257326380
of35932529012885132
Corynebacterium376025290128109179227297365428497560622660723770809878988
diphtheriae47812529012886126195265305374437484522584647
-54632529012868
gram-positive8512771012870117180289334404474529568607646715778
rod-shaped166427710128120189260307361431494563626696
bacteria239627710128141204265304367413452515
of294627710128141189
the317027710128110181244
Corynebacteriaceae344827710128166236282353421484554617679717780827865927990105111131176
family.466227710128120182291328367438471
Nontoxigenic5168277101281742443148513012012839110179219288351420459521
strains14083012012866105152214253322377
can18203012012875137206
colonize20623012012874144184253323362424486
mucous259630120128110177240310380435
membranes307930120128110170279347394456526589644
but37593012012881152190
do39853012012882151
not41723012012883152191
cause43983012012875137207262324
disease47573012012882121175238300354417
[1,52093012012859128164
2,54083012012881117
3].8513254012870117151
•12053495012849
Morphology:129634950128125195242311382452490561630701738
Thin,20763495012886156195266301
slightly2413349501285999137208278316355426
curved28723495012869140187257319389
rods32973495012853122193247
1-835803495012875126197
µm38123495012888196
long,40413495012846117187257292
arranged43683495012869116163225294365428497
at49003495012869108
an50443495012869138
angle52183495012869139208247310
to8513737012839110
each9953737012873135198267
other,12973737012880118189252297332
forming16643737012857126173283319390461
characteristic21603737012873142205251313375414476523562616655694756
figures2950373701285796166236283344399
such33843737012864135197267
as36853737012873126
a38473737012873
Roman39643737012894164274334404
numeral44033737012880150260320367429468
V,491737370128101136
splayed50883737012864134173235306366436
fingers,851397801284786156226289336389425
or13113978012882130
a14753978012876
picket15863978012883121184254316355
fence.19763978012860122192255317352
•23623978012863
Staining:24603978012892130193230301340409480518
Gram-positive.302839780128101147210318366436507562601640679748811846
Neisser392339780128101163201256310373420
stain43763978012869107170209279
reveals46893978012861123193255318356411
yellow51343978012884145184223294395
rods8514220012847117188242
with112842200128102140178249
dark14114220012870133180249
blue16954220012870109178241
or19714220012870116
purple21224220012871141188257296359
volutin25164220012870139178248287326396
(polyphosphate)29474220012847116187225296364435504558629699761799862909
grains38904220012870117179218288342
at42674220012863102
the44044220012838108170
poles.46094220012871140178241296331
•12054461012849
Cultural128944610128155225264303373420482521
properties:184644610128129177246316379425464502565618658
Facultative253944610128139202264333371411474512550621683
anaerobes.325844610128123192254317362432502564619654
Grow394744610128162208279380
on436244610128131201
special459844610128116185248309348411449
media:508244610128172232302341404442
Clauberg's8514702012894133195265335397444514540593
medium148047020128149209279319389499
(tellurite-blood20124702012888127190228267337384422461524573642681751821891
agar):293847020128103173235282328366
forms33404702012887157205314366
black374147020128111149212275344
or412047020128111158
gray-black431347020128109156218288336406445508570641
colonies,498947020128102172210281351389452506541
Roux's8514945012894164233304330383
medium127049450128109168239278349459
(serum-tellurite17614945012847102164211281390437476538577617687734772811873
agar),26694945012862133195241288323
liquid3027494501283877147217255326
media:338949450128109168239278341379
produces38034945012871117187256327390451506
uniform43434945012870140179226295342452
turbidity.48274945012839110157227266335375413484517
•12055186012849
Biovars:128951860128137176245315378424478517
Three184151860128128198245308369
main224551860128152213252323
biovars260251860128112151221292354400455
are309151860128106152215
distinguished334051860128113151205245283353424493532587656719788
based416451860128111174228290361
on455951860128112183
cultural477651860128104174214252322369431469
and528151860128105174244
biochemical8515427012870110179242311374483520583645684
properties:15715427012870117186255318365403442504558597
•12055668012849
gravis12895668012870117180249288343
-16675668012847
forms17495668012847117163272325
large,21095668012839101148218282317
flat,2459566801284786148187223
radially27185668012846108177216278318357427
striated3178566801285594142181242281344413
colonies,36275668012861131170240310349411466501
ferments41635668012846109156265325395435489
starch;4687566801285593156201264334374
•12055911012849
mitis129059110128109146185225279
-16045911012847
forms16875911012846116164273325
small,20485911012854164224263302338
convex,24215911012862132202272335404440
black28955911012870109171234303
colonies,32335911012863132171241310350413466502
does37695911012870140203257
not40605911012871140180
ferment42755911012847109156265325395435
starch;4745591101285393155201264334376
•12056152012849
intermedius12896152012839109149211258367427497537607662
-19866152012847
intermediate20686152012838109147210257366427497537599638700
properties.28026152012870117186257319366405443506559596