438
Task639596010880130176243
5.91259601086090
Complete1033596010886146246311345398438491
the1553596010840107160
table1743596010841101168202255
"Biomedical2028596010867147181241341393459493546606639
Research2697596010887140186239299353405471
Design"3199596010886140186219279346413
Design639873011087140186219279338
type100787301103496154208
Characteristic2093873011080140194233286339372425466499546579612666
Advantages27898730110165225285338397431484545597643
Flaws34648730110144177230317363
Application38598730110164224284318351404458490524584644
examples4533873011053113167260320353407453
Randomized6391016011080134193253313406440493547607
controlled12761016011053113173206246306339373426486
trial1792101601103373106160193
Cohort6391159011080140200260300334
study1003115901104680140200261
Long-term6391302011073132192253293326379419512
observation11811302011060120167220260320374407440500560
Meta-analysis63914450110107160193246286340400453486547591625671
Experimental6391587011073133194248287320414467527560613647
study1316158701104680140200261
Compare6391869011080140234294347387440
research1108186901104194140194248287340399
methods15391869011093147180240300361408
in1977186901103494
terms2101186901103588128221268
of:23991869011061101134
evidence,25631869011055114148208261321374427456
degree30491869011061115174214267320
of33981869011061102
control,35301869011054114174207247307341371
time3931186901103467161214
of41751869011061101
implementation,43061869011034128188221275368421481514568601634694754784
resource5120186901104295141201261301354408
intensity.639200701103393127180240287320353415434
Task6392288010880130176243
6.912228801086090
Case10322288010887147194247
discussion13082288010867101148201268314361395455521
Case6392560011080140187240
1.909256001106090
A6392698011087
new7482698011089142229
surgical10072698011076136175234266319374406
method144326980110123176209269329389
for18632698011069129169
treating20612698011062102157209242276336396
lower24872698011062122209262301
extremity28192698011082142176216269362395429490
venous33372698011089142202262322368
diseases37362698011089122169222276322375421
is41872698011063111
being43282698011088142175235295
developed46532698011088142201255287347407461522
at52052698011081114
the53492698011063123177
Vascular6392836011087126173226286319372412
Surgery10812836011089149189248301341402
Center.151128360110103156216249304343367
A190828360110109
randomized20402836011064118177237297391424477531591
trial2661283601105696129183216
is29072836011056102
planned,30392836011084117170230290343403433
in35022836011056116
which364828360110109169203256315
the39932836011057117170
control41932836011077137197231271331364
group45872836011083122182242302
will491928360110110143176210
receive51592836011063116169221254314369
standard639297401104780133193253307346406
surgical10752974011080140180238270324378411
treatment,15162974011067107160213246339394453487517
while206329740110120180213247300
the23932974011067127180
experimental26032974011086146207260300333427480539573626659
group32922974011094133193253313
will363529740110119153186220
undergo38852974011093153213267306365423
surgery43392974011081141181238291331393
using47592974011094140174234295
the50832974011067127180
new52932974011093147233
method.6393111011093147180240300360390
To6393249011073125
prevent7943249011075115169228282342375
patients11993249011076129162195249308342388
from1617324901105797157251
experiencing18983249011069129190243282316369428482515575636
potential25633249011075135169222282315349402435
stress3029324901106296136189235282
associated33413249011070116163223276310363396449509
with388132490110102135169229
learning41403249011049103156196256289349410
that45793249011049109163196
a48053249011069
new49083249011076129215
method51703249011093146180240301361
will6393387011087120153187
be8563387011067120
tested1006338701104094140174227287
on13233387011067127
them,14803387011040100153247277
the1786338701104099152
study's1968338701105487147207268288334
organizers23323387011068107166218278311364418458504
decide28663387011067121173207267321
to32173387011040100
conceal33473387011060120180233286339372
its3749338701104074121
details39003387011067120153206240273320
from4250338701104686145239
the45193387011040100154
patients—for47033387011066120153186240299332379503543603643
the53753387011041101154
benefit6393525011060113173226266299332
of10013525011060100
the1131352501103494147
patients13073525011060115148181235294328374
themselves.1711352501103494147240287340374434487533563
According6393663011087140192252292352385445506
to11743663011057117
the13213663011058118171
researchers'15223663011064117163216270310364423476516563585
plan,21363663011084117170230260
subjects24263663011071131191224277330363410
will286636630110111144177211
be31073663011084137
asked32743663011077123183236296
to36003663011057117
consent37473663011078137197244297357390
to41673663011058117
participate43143663011084137176210243296329389443476529
in48733663011057117
the50203663011058118171
study,52213663011070104164224283303
information639380101103393133193233326380413446506566
about12353801011054113173233266
which15313801011087147180234294
will18563801011086120153186
be20733801011060113
communicated22153801011054113207300360420454507560593646706
only29513801011060120154216
in3194380101103494
general33183801011061113173226266320352
terms.3700380101103487127220267297
The6393939011073133187
organizers8553939011066106164216276309363417456503
submitted13883939011052112172265299332366419479
an18973939011059119
application20463939011059119179212245299352385418478538
to26143939011040100
the2744393901103999152
ethics2926393901105992152185239285
committee,32413939011060119212306340373407460513542
but38133939011066126160
the4003393901103999152
committee's41853939011059119212306339373406460513534579
experts47943939011060119180234273306353
did5177393901106699159
not53663939011066126160
approve6394077011053113173213273333386
the10544077011041101154
project.12384077011067107167200253307340370
Their16384077011081141194227268
conclusion19364077011060119179233266326372406466526
stated2492407701105487141174227287
that28094077011040100154187
patients30264077011067120153187240300333380
must34434077011094154200234
be37074077011067120
fully38574077011047107140174235
informed41184077011041101141201242335388448
about45964077011060120180240273
the48994077011041101154
nature50834077011067123156216256310
of54224077011067107
the639421501103393147
proposed8164215011060100159219279326379439
study.1285421501104680140200261281
The6394353011073133187
researchers,8554353011048102147201254294347407461500547577
for14624353011048108148
their16394353011042102155189230
part,18994353011068121160194224
state2153435301105588141175228
that24104353011042102155189
the26294353011041101155
new28144353011068121207
method30594353011094147180240300360
does34494353011068128182228
not37074353011068128162
pose38994353011068128174227
an41564353011061121
increased43074353011041101155195247300346400459
risk4796435301104882128188
to50144353011042102
patients51464353011069122155188242301335381
compared6394491011053113206266319359412472
to11424491011040100
previously12724491011067107161221254314374421455516
tried1815449101104182116169228
standard2073449101105487141201261314354414
surgical25174491011054114155213246299352385
procedures.29324491011067108169222275334394434488533563
The35274491011080140193
researchers37514491011047100146200253293347406460500548
are4329449101106099153
confident45124491011060120180221254314368427460
in50024491011041101
the51334491011041101154
new53184491011067120207
method,6394629011093147180240300360390
as10594629011088134
it12234629011068102
has13554629011095148194
successfully15794629011082142195248301347395434494528561623
passed22294629011095148194241294354
preclinical26134629011095135189241274308368401456509542
trials.31854629011068108141195228274304
They351946290110109169222282
also38294629011089122169229
believe40884629011095148181214268327381
that44984629011068128182215
overly47434629011095155208247281342
detailed51124629011095148181236269302356415
information639476701103393133193233326379413446506566
about12354767011073132192252286
this15514767011052112146193
new17744767011079132218
method202247670110113166199259319379
could24314767011073132192225285
itself2746476701105386134187220260
cause30364767011072125184231284
stress3350476701106699139192238285
in36654767011053113
patients38084767011079132165199252312345392
and,42304767011074133193223
therefore,44834767011053113166206259298358399452481
potentially49944767011079139173226286319353406439473534
cause6394905011053106166212266
more9344905011094154194248
harm12114905011060114153246
than1487490501103494147207
the1724490501103393148
surgery19014905011047107147205257298360
itself.2289490501103366113167200240270
Questions6395043011087147200246279313373433480
for11495043011040100140
discussion:1318504301106093140193253300347380440500534
1)8195181011060100
Who99951810110113174234
is1263518101104288
right1380518101104982142201234
in16445181011042102
this17765181011043103135182
case:19885181011062114161214247
the22655181011042102155
ethics2450518101106194154188241287
committee27675181011062122215308342375408462514
or33115181011068108
the34495181011041101155
researchers?36345181011048101147200253292346405459499545599
Use42725181011087134187
the44895181011041101154
material46805181011094147180234273306360392
from5102518101104989148241
the53735181011042102156
Declaration9995319011087140192225279319372405439499559
of15885319011065105
Helsinki,17275319011087140172219253313373406436
New21975319011087140226
Standards24535319011071105158218278331371431477
for29605319011045105145
Medical313953190110106160219253306359392
Research,35665319011080133179233286325379439469
and40655319011058117177
the4272531901103898151
Code44585319011080140199252
of47405319011064104
Ethical48795319011073106166200253306339
Rules52535319011080140174227273
for9995457011040100140
Conducting11685457011080140200260320374407440500560
Clinical17575457011080114147208241294347380
Trials21665457011073108142195228275
and24715457011053113173
Biomedical26755457011080112172266319379412466519551
Experiments32565457011074134195248288321414468527561607
on38935457011060120
Human40445457011086146240293352
Subjects.44265457011067128188221274327360407437
2)8195595011060100
Consider9995595011080140200247280341394433
how14625595011060120207
it1699559501103367
would17965595011086146206240300
be21265595011060113
most22695595011093153200233
morally25325595011094154194247280313375
correct29345595011054113154194247301333
to3297559501103494
organize34215595011060100159211270304357411
this3861559501103494127174
research.4065559501104093139193246286339399429
Case6395871011080140187240
2.909587101106090
A6396009011087
doctoral7486009011080140194227287327381414
candidate11926009011074126186246279339394427480
applied17026009011073133194227261314374
to21066009011053113
the22496009011054114168
medical244760090110113166226260313366399
school's28766009011067120180241301334356401
research33076009011061115161214267308361420
ethics37576009011074107167200254300
committee40876009011075134229322356389423476529
for46466009011060120160
permission48356009011080134173267300347393427487547
to54126009011054114
conduct6396147011053113173233293346379
animal10486147011055114147241294327
testing1405614701103588135168202262323
on17586147011060121
white19106147011087147180214267
mice.22086147011093126180233262
The25016147011074134188
submitted27186147011048108168262295330363417476
study3224614701104882142202263
design35166147011060114160194254313
and38606147011054114174
the4064614701103494147
accompanying42426147011055107160220313373428487549579639701
report4973614701104198157217258292
from5295614701104181140234
the639628501103393147
committee8166285011057117210304337371404458511
meeting13616285011093147201234267327387
stated1778628501105285140173226286
that2094628501103898151184
the2308628501103898153
animals24906285011060119153246300332379
would29046285011087147208241301
be32356285011065118
treated3383628501103878132185218271331
after3745628501105897131185224
participating39996285011065119158192225278312372426459492552612
in4641628501103898
the4769628501103898152
experiment,49516285011059119180233272306399452512545575
and6396423011053113173
those842642301103393153200253
who11256423011087147207
were13626423011086139180233
resistant1624642301104094140173220254307367401
to2055642301103393
treatment2178642301103374127179212306359419452
would26606423011087147207240300
be29906423011060113
euthanized.31336423011054113146206260320353406460520550
The6396561011073133187
ethics855656101105386146180233279
committee11646561011054113207300334367401454507
did1701656101106093153
not18856561011060120154
approve20696561011053113173213272332386
the2484656101103393147
research2661656101104093140193246286340399
until30916561011060120153187220
further33416561011040100140173233286326
documentation36976561011060120173233326379439473526559593653713
was44406561011087140188
provided.46586561011060100160220254314367427457
What63966990110113174227260
additional9296699011053113173207240273334394447480
documentation14396699011060120173233327380439473526559593653713
did2182669901106093153
the2365669901103494147
ethics2542669901105386146179233279
committee28516699011053113206300334367401454507
request3387669901104094153213266312346
and37636699011053113173
why?39666699011087146209261
Case6396975011080140187240
3.909697501106090
The6397113011073133187
research8557113011060114159213267306360420
team13057113011053107160252
is15877113011054101
developing17187113011081134195248281341401434494554
an23017113011074133
innovative24647113011054114174234294349381415475528
drug30227113011081121181241
for32927113011061121161
the34837113011053113166
treatment3679711301105494148201234327381440474
of41837113011080121
cardiovascular43347113011073126166226259319379433479533592626679719
diseases.50827113011081114161214268314368415445
Preclinical6397251011067107160213246279339373426479512
trials1181725101105494127180213260
are14717251011074113167
planned,16677251011080114167228288341400430
and21277251011074134194
the23517251011053113166
team25477251011054107160253
is28307251011054101
tasked29617251011054106152212265325
with331672510110107140174234
selecting35807251011069122155209262294328388448
the40577251011054114167
optimal42557251011080140173207300354387
research46727251011060114159213266305358418
method,512072510110113166200260320380410
taking639738901103387147180240300
into9687389011056116149210
account12087389011076128181241301361394
the16327389011056116170
"three18327389011072105165205258312
Rs"217373890110103150199
principle.24017389011083122156216269302362395449478
The29097389011096156211
following31497389011063123156190250336370430490
research36677389011063117163217269310363422
options41197389011083143178211271331378
are45277389011076116169
available47257389011076135189222255309368402455
to52107389011056116
the53567389011056116170
research639752701104093139192245286339398
team:1067752701103487141234267