277
5554147819011156112
Hyperfermentemia106559601281011722403033503974595066156757457858489579941056
in2156596012840110
Cardiovascular2300596012894156203273312382452515568631700739802848
Diseases.318359601281011391952563183724354893674599012635
The3744596012886155218
main39965960128110169208279
cause4311596012863125195249312
of4655596012871118
increased4809596012839108171218280342396459528
enzyme851839012862133195266374434
activity1320839012863125164203274312352423
(and1776839012847109179248
content)2060839012862133202241304373412459
in2554839012839108
the2698839012839108171
blood2903839012870109179249319
serum3258839012853115162231341
of3632839012870117
patients3784839012870133172211273343382437
is425683901283893
the4384839012838107170
destruction4589839012870132187225272341404443482551622
of5245839012870117
myocardial85110800128109178247309372418489528591631
cells15171080012862125162201256
and18081080012863132201
the20451080012839109172
release22521080012847108147210271325388
(flushing)2675108001284793132201256326364435505552
of32601080012871118
released34131080012847109147209272325388458
cellular39071080012861123162200270310372418
enzymes43601080012862131194264373433487
into48831080012839109149219
the51371080012839108171
blood8511321012870110179249320
(acute12061321012847109170240279342
myocardial158313210128109178246309371418488527589628
infarction,22471321012837108154217263326364403473543578
myocarditis).286013210128109178246309371418489529567607661708743
For36381321012878147194
the38671321012839108171
diagnosis40721321012870109172241311382436475529
of46371321012870117
acute47891321012862123193232295
myocardial85115630128109178247309372418489528591630
infarction,15161563012838109156217264326364404473544578
determining21291563012870133172235281391427498536607677
the28411563012839108171
activity30471563012863125163201271310349419
of35001563012870117
several36521563012854117187249296358396
enzymes40841563012862132194264373435490
in46091563012839108
the47531563012839108171
blood49581563012870109179248319
serum8511805012855117164233343
is1227180501283993
particularly13561805012870133179218257320389429490537576647
valuable:20361805012870133172242306375413476515
1.10652046012870106
Creatine12112046012894141203265305343413475
phosphokinase17212046012871140210265334404475544584653716770832
(CPK),25882046012847141219320366401
especially30242046012862117186249310349412450490560
its3617204601283978133
MB378520460128125219
fraction4039204601284691154216254293363434
(MB-CPK).45082046012847170264314406484586632667
2.10652288012870106
Lactate12112288012886148210249312350413
dehydrogenase16592288012870133202273341388458528591660722776838
(LDH)25322288012847132233334380
and29472288012862133203
its3186228801283977131
isoenzyme3352228801283993164226295357427536597
139842288012871
(LDH1).40902288012846132233334404451486
3.10652529012870106
Aspartate121125290128102156226289336374437475537
aminotransferase17832529012863172208279350388435498567622668730777839894956
(AsAT).27742529012846148202304389435470
10652781012865
Creatine12052781012894140203265304343412475
kinase17152781012874112183244299361
is2111278101284297
found22442781012850119188258329
in26082781012841112
all27552781012866104142
muscle293627810128109177232295334397
tissues3368278101284280135190259321376
and37792781012866136206
is4020278101284196
nonspecific41522781012872143212267337400461500547585648
for48352781012848119166
myocyte503927810128110178247310381418481
injury;8513022012839110149219265335372
however,12593022012877148249311380443490525
CK-MB18263022012893195242366459
is23203022012846100
relatively24563022012853116155216255294365426465536
specific30253022012862132195257295342381443
for35033022012854124171
myocardial371630220128110178247310372419489527590629
tissue.4381302201284483137192262324359
Elevations47823022012886124187256319357396466536591
in54083022012845114
CK-MB8513263012894195241366460
must134632630128110177233272
be16533263012871134
interpreted18223263012839109149211257327374437475537606
with246532630128101139179248
caution27493263012863125194233272342412
in31963263012840110
situations3341326301285594133203266304343413482537
where391532630128101169232279341
skeletal42913263012855125187226289327390429
muscle475632630128109177232295333395
injury51873263012839109148218265335
or8513506012870117
disease10033506012871109164226288342404
is1442350601283993
also15713506012862101155225
suspected,18323506012854123178248311373411474543578
as24463506012861116
CK-MB25983506012893195242366460
is3093350601283893
released32213506012845108147210272326388457
from3714350601284793162272
damaged40193506012870132243303373436506
skeletal45613506012854124186224287325388427
muscle.502335060128109177232295334396431
10653757012865
Previously12053757012878125187257296366436490530600
used18383757012885140202271
in21453757012852122
conjunction23033757012875144215254323393456494532603673
with301437570128101140178249
CK-MB,329837570128107208255380473508
lactate38413757012853116178216279317379
dehydrogenase42563757012883145215286355402471541603672735790851
is51433757012853107
also52853757012876114169239
no8513999012870141
longer10263999012840110179250313358
regularly14193999012848110179249289351397436507
used19603999012870124187257
for22513999012848117164
diagnosis24503999012870109172242311381436474529
of30143999012871117
myocardial316639990128109178246309372418489528591630
injury.38303999012840110149219266336370
Lactate42353999012886148210249312350413
dehydrogenase46833999012870132202272341388458528590661722777839
is851424001283994
found9814240012862131200271340
in13574240012853124
many153142400128109169240310
tissues1875424001285493148202273336389
and23004240012877146216
is25524240012854108
therefore26984240012855124187234295342412458521
not32534240012885156194
specific.34834240012868139202263302349387450485
It4003424001286199
also41384240012877115170240
takes44134240012853116186248303
several47514240012869132201264310373411
hours51974240012884155225272325
after8514481012862109148211258
onset11424481012871141195258296
of14744481012870116
injury16264481012837107147216263334
for19934481012847117164
levels21924481012839102171234271327
to25544481012838107
become26974481012870132195264374434
elevated.31664481012862101163234296335397466502
10654732012865
Changes12054732012894164227296366428483
in17224732012842112
AST187347320128101179265
activity21724732012866128166204274313352422
are26284732012865112174
nonspecific.28374732012874144213268338401463501548586649684
The35584732012885155218
level38114732012841104174236275
of41204732012874121
AST,427847320128101179265299
along46124732012865104174245314
with496547320128101139178248
ALT525147320128102187272
activity,8514975012862125164202273311351421455
increases13414975012838109172218280342396458513
in18904975012837108
many203249750128109170240311
pathological23764975012871133172243314352422492531593656694
conditions,31054975012863131201272310350388458528582618
including37584975012838108171209279349387458528
liver4321497501283977147210256
diseases.46114975012870110164227289342409463499
"Cardiac10655216012857151213260329369432493
enzymes"15935216012865135197268376436491549
is2177521601284297
a23095216012865
broad24095216012874121190253322
term27675216012841103150259
encompassing30595216012866136199269379446509564618656727797
several38915216012857119189251298360398
intracellular43255216012841112150197260322383422462531570633679
myocyte504352160128109178246309379417479
components8515457012862133242310381451514583622677
that15635457012845115177215
can18145457012868130199
be20495457012875138
found22225457012853123192262333
in25905457012844114
serum27405457012859122168237347
and31205457012868138210
measured337154570128109169231286357404466537
under39435457012875145215278324
certain43035457012868130176213276315385
circumstances47235457012868106153216285394447486549619682743797
such8515700012855125188257
as11445700012881135
myocardial133457000128109178246309371418488528590629
ischemia,19985700012858112175245307416453516551
trauma,25845700012857105167237347407442
myocarditis.306257000128129198269331394440510549588626681717
In38145700012865135
the39855700012858127190
proper42105700012888135205275337384
clinical46295700012881120159229268330392430
setting,50955700012873136175214252323392427
elevation8515941012862101164233296335373443514
in14005941012869140
the15755941012870139202
level18125941012870133202265303
of215059410128101148
enzymes23335941012894163225296404464519
present288759410128101149211266327398436
in33595941012869139
serum35335941012886149195264374
is39405941012870125
key410059410128101164234
in43675941012870141
the45425941012870141204
diagnosis47815941012899139201271341410465504559
of537559410128100146
myocardial85161820128109178247309372418489528591630
infarction.15166182012845115162224271333371410481550585
While214261820128133201241280343
troponin2520618201284592161232301371410480
is30356182012845100
the31716182012844114176
most338961820128109177232271
commonly36966182012869138248356423494533604
used43336182012877132195265
cardiac46346182012869130177247286349411
enzyme50796182012869139201271380440
for8516423012847117164
diagnosis10506423012891130192262332401456495550
of16346423012892139
myocardial180764230128130199268332394441511550612650
infarction,24936423012860130177239285347386425494565600
others31286423012890129198261308361
exist35256423012883153192246285
and38456423012884153223
may410464230128130190261
be43996423012891154
helpful45886423012890153191262309378416
in50406423012860130
some52056423012875145255315
situations851666501285594133203265304342413483537
(Tab.14246665012846132194264300
2).17576665012870117153