419
3954097556011060120
Children851752011080140174207267307361420
who1301752011086146206
have1537752011060114173226
not1793752011060120153
previously1976752011060101155215248308368415449510
received251375201104094147201234294347407
ARVs2950752011087166253300
as3280752011054100
treatment341075201103474127180213306360419453
are389375201105494147
prescribed4069752011060101154200254294328388442501
a4600752011054
starting468375201104780134173206240300361
treatment507375201103373128180213307360420453
regimen85191101104093153186279333392
of1273911011076116
21419911011075
NRTIs15249110110102182255296341
and1895911011070130191
a2116911011069
third2214911011049109143183243
drug2487911011075115175236
or2751911011076116
12897911011075
NNRTI30029110110102189269343384
or3413911011076116
13559911011075
AI36649110110103144
or3836911011076116
1IP.3982911011075117181211
In4223911011057115
other4368911011077110170224264
cases,4661911011069122168222269299
a4990911011068
3-ARVP5088911011080120206286373440
scheme8511069011047100160213306359
is1240106901104693
used13631069011073120173233
as16261069011068114
a17701069011066
starting1866106901105993148187221254315375
therapy22701069011046106159199253313375
in26721069011047107
children28091069011067126159193253293346406
for32461069011054114154
effective34291069011066106147200253286320380433
HIV39051069011087127212
suppression.:41481069011060120180240280333380427460521581611644
248221069011073
NIOT49381069011087128213286
+52541069011081
the53641069011047107161
third851122701103393127167227
drug11081227011078118178238
from1374122701105898158252
the16561227011051111164
group18501227011078118178239299
of21791227011077117
AI232612270110105145
or25001227011078118
IP26481227011058123
or28021227011078118
NNRTI.295012270110104190270345386413
The33931227011091151205
use36281227011078124178
of38351227011078118
defective39831227011078132172225278311345405458
schemes44721227011064118177231324377423
leads49251227011052105158217264
to52191227011051111
the53601227011052112165
development8511387011060113173226259319379472526585619
of15001387011066106
HIV16411387011087128213
resistance.1884138701104699145178226260313373426479508
In24221387011047106
adults,25581387011059118178212245292322
when29161387011087147200259
choosing32051387011060120180240287320380440
starting3674138701105386139179212246306366
therapy,40691387011041101155195248308370398
it4498138701103972
is4601138701103986
recommended4716138701104699151211304398451511571624684
to5430138701103999
use8511545011060107160
less1041154501103386133180
toxic1251154501103393153188241
and15221545011053112172
most17241545011094154201234
convenient19881545011053114174234288347380434494527
treatment2545154501103373127180213307360420453
regimens3028154501104093154186281334394441
in3499154501103393
the3622154501103394147
form37981545011040100141234
of40621545011060100
combined41921545011054114207267301361414474
drugs46961545011060100160220266
in4992154501103393
the5115154501103494147
form52921545011041101141233
of8511704011060100
fixed-dose981170401104073133187247287346406453506
combination15171704011053113206266299360413446479540600
drugs.21471704011060100159219265295
In881186201104198
the10101862011053113166
treatment1206186201105292147199232326379439472
of17081862011079121
adults18591862011072131191225259306
and21951862011072132192
children,24171862011072132165198259299352411441
preferred28891862011079119173213266305346400459
schemes,33781862011066119179232325380426456
alternative38641862011073105139192233293346379412473526
schemes44191862011067121180233326380426
and48751862011074133193
schemes50981862011066119179233326379426
used8512022011060107160220
in11012022011053113
special12442022011068128181234267320353
cases16272022011074127173226272
are19292022011074114168
accepted.21262022011074126179233293326379439469
The26252022011094154207
choice28612022011074133193227280333
of32242022011081121
ART337520220110107187260
regimen36652022011060113173205298352411
is41062022011054101
made423720220110114167227280
taking45462022011054107167201261321
into48962022011053113147207
account51332022011073126179239299359392
possible8512180011060120167213247307340394
contraindications12752180011053112172206246299332392452485539591624658718778826
to2131218001103393
the2254218001103494147
appointment24312180011053113173233266326359453506566600
of30612180011060100
individual3190218001103494154187247281341401454487
ARVs37072180011087167254300
and40372180011054113173
risk4240218001104073120180
factors4450218001104093146179239279325
for48052180011040100141
their4976218001103393147179219
use.52252180011060107160190
Table8512339011073127186219273
2.1154233901106090
Treatment12742339011073113166219252346399459492
failure1796233901104093126159220260314
criteria2139233901105493126160213253286340
and25092339011053113173
management27122339011093146206260320373466519580614
tactics3356233901103387139172206259305
Criteriafor8512502011080120154187240280313366406466506
ART13862502011087167240
failure1656250201104094127160221261314
Definition24462502011087140179213273306339373433493
Tactics40412502011073127179212246299345
Virologicalfailure8512645011087120160220253313373405459513546586639672705765805859
HC>508512788011087167234294354
copies/ml12352788011057116176210263310343436470
or17352788011064104
above18692788011056116176236289
the2187278801103797150
detection8512926011060113146199253285319379439
threshold1320292601103393133187233293353386446
Repeated24462788011080134193246299332385445
(with29212788011063149182215276
an32272788011075134
interval33912788011055115148202243303357389
of38102788011082122
2-424462926011060100160
weeks)263629260110205258312371418458
detection312429260110178233266319372405438499560
of371429260110178218
detectable24463064011060113146199253285339399432485
BH296230640110139225
levels32173064011092146206259291338
(more358530640110100194254294346
than2446320201103393147207
50268332020110116176
copies/ml288932020110109169229262315362395489522
or344132020110117157
more362932020110149209249302
than2446334001103393147207
the26833340011072132186
detection28993340011099152185238291324357418478
threshold)34073340011073133173226272332392425486526
after2446347801105393126179219
6269534780110111
months283634780110145205265298358405
or327134780110112152
more345334780110145205245298
of378134780110111151
ART24463616011087167240
in2716361601103898
patients28443616011065118151184238298331378
with32573616011086120153213
achieved35003616011058112172206259319373432
virological2446375401106093133193227287347379432486518
suppression29943754011047107167227267321367414447508568
Switch40412788011067154187220274334
to44052788011052112
second-line45472788011066119172232292352392425459519572
ART514927880110106184258
if5437278801105292
there4041292601103393147187239
is431029260110151197
good453729260110178237297357
adherence492429260110171230290344384437497550604
(according4041306401104093146198258299359392452513
to4583306401103898
the4711306401103898152
results4893306401104498144204238271318
of52413064011065105
the5376306401103898151
resistance4041320201104093139172219253306366419472
test).4758320201103387133167207237
When524232020110113174227287
violations4041334001106093153187240273307367427474
of45453340011084124
commitment46993340011076136229323356390483537595629
are53583340011077117170
detected,40413478011060113146199253285339399429
preliminary45003478011087127180213246340373433487526588
work511634780110114175215275
is54213478011060107
carried40413616011053106146186218273332
out440336160110199259293
to472636160110172232
improve498836160110173266327367427487540
commitment.40413754011053113206300333367460514574607637
Immunologicalfailure85138970110401322252853454054394995605926466997327718268598929529921046
There8514040011073133187226279
are1159404001105594148
no13364040011060120
clear1486404001105487140193234
criteria1750404001105392126159212252285339
Reduction24464040011080134193253306339373433493
of296940400110199239
CD4+323840400110219306366433
to370140400110172232
baseline24464178011060113159213246279339393
and286841780110189249309
below,320741780110195249282342429459
or369741780110195235
persistent24464316011060113153199233279313366426459
CD4+29354316011080167227295
<10032594316011068128188248
mcl35374316011093148180
In4041404001104098
the4380404001103393147
presence47674040011060101154200253313367420
of54274040011060100
leukopenia/lymphopenia40414178011033871472072673273804394735265595936547458058659259851039109911321186
–54694178011060
cause40414316011053106166212266
analysis43364316011053113167200263307340387
and47534316011054113173
correction49564316011054113153194247299333367427487
Clinicalfailure8514458011080114147207241294347380420473506539600640693
There8514601011073133187226279
are1159460101105594148
no13364601011060120
clear1486460101105487140193234
criteria1750460101105392126159212252285339
New24464601011087140226
or270246010110154194
recurrent292646010110135189241301341381435494527
clinical348346010110148181216276309363416449
condition24464739011053113173233266300333393453
after29294739011099139172225265
6322447390110105
months335947390110139199259292351398
of378747390110106146
effective2446487701105393133185239272305366419
treatment2895487701103373126180213306360419453
Individualapproach4041460101104098158192252285345405459492545605665706766819873932
When85150220110113174227287
obtaining11685022011097157190243277337370430490
clinical16875022011091123157217250304357390
and21075022011090150210
laboratory23475022011070124184244283336369429469531
data29055022011098151184237
confirming31725022011090151211251284324417451511571
the37725022011070130183
ineffectiveness39855022011071131184224263317370403436497551610664710757
of47725022011097137
ART,493950220110123203277307
it52765022011070103
is54105022011070117
necessary8515181011060113166219265312365406468
to1346518101103696
conduct14725181011057117177237297350383
a18855181011055
molecular19735181011094155188242295354388441481
genetic24835181011064117177230263296350
study2862518101104983143203265
(sequencing)3155518101104390144204264317376430462522584623
of38085181011063103
blood3941518101106195155215275
plasma4246518101106296150196293346
for46225181011042102142
the4794518101103595150
presence49735181011063103157203256316369423
of54255181011063103
drug8515339011060100160220
resistance10995339011075129175209255289342402456508
mutations163753390110128188221275308341401462509
in21765339011068128
the23345339011068128182
RNA254653390110114201288
of28635339011095135
the30285339011068128181
human32395339011094154248301361
immunodeficiency36305339011068161255315375435495548588621674707761820874934
virus45925339011094128168228274
HIV-1.489653390110122164249292351381
The530753390110108168222
formation8515498011040100140233286319353413473
of13545498011076116
drug15005498011077117177237
resistance17655498011057110156189236270324384437490
occurs22845498011077130184244284330
with264454980110103137170230
the29045498011050110164
accumulation30985498011069122175235328388421475508541602662
of37905498011076116
several39365498011063116176229269322355
primary43215498011077117150243297336397
HIV474554980110104145230
mutations,50215498011093153187240273307367427474504
secondary8515656011047100153212272332386425487
mutations13795656011093153186240273306367427473
do18825656011072132
not20445656011073133167
lead2241565601104599152211
to24825656011045105
drug26195656011072112172232
resistance.28805656011053106152186232266319379433486516
If3426565601105492
drug35485656011072113175236
resistance38135656011052106152185232266319379432485
is4328565601104692
detected,44505656011074127160213267299352412442
this49235656011046106139186
class5139565601106598151198245
of54145656011073113
drugs8515816011060100160220265
is1146581601103380
not12565816011060120154
prescribed.14405816011060100153199254293326386440499529
Another8815974011087147207240300353393
important13045974011042136196256296329383442475
aspect18095974011063110170223277310
of21495974011069109
therapy22885974011043103156196249308371
is2685597401104389
the28045974011044104157
treatment2991597401104383136188221316369429463
of34845974011069109
secondary36235974011056109162222282342395434496
and41475974011063122182
concomitant43595974011063124184237296390423457510570603
diseases49925974011070103150203257303356402
in54245974011043103
HIV8516133011087127213
infection.1094613301103494134187240273306366426456
In15806133011042101
their1711613301103494148181221
severe19626133011047101161215254307
course,22996133011054113173214261314344
as26736133011054100
a28036133011055
rule,28876133011041101135189218
it3135613301103568
is3234613301103481
secondary33456133011048101154214274334387426488
and38616133011054114174
concomitant40656133011055115175228288381414449503563596
diseases4691613301106194141194248294347393
that5114613301103595148181
take5325613301103588148201
priority8516291011060100133193233266300361
of12406291011060100
treatment1370629101103373127180213306360419452
before18526291011060114154214255308
starting2190629101104680133173206239299361
ART25796291011087167240
in2849629101103494
patients29736291011060113146180233293327374
who33776291011087147207
have36146291011060113174227
not38716291011060120153
received4054629101104093147200233293346406
ARVs.44916291011086166253300330
With85164510110113147181241
CD4+11256451011080167227295
values14496451011064117150210263310
<35017896451011072132192252
kl/µl,2071645101106498131201234264
primary23656451011064104137231284324384
prevention27776451011065105158217271331364398458518
of33256451011063103
opportunistic34586451011063123183243285318378438471518551585638
infections4126645101103797137190243276309369430477
is4633645101103784
carried47476451011057110150190223276336
out51146451011063123157
after5301645101105797131184223
their851660901103393147180220
presence11016609011060100153199252312366419
is1549660901103480
excluded.16596609011054114168201261321374435465