325
3754097556011060120
Treatment2916597010880134186246286387438505545
ThemaintreatmentforpeopleinfectedwithHIVisantiretroviraltherapy.8518520110731331872793333664264594995536056387327858458789189781019107911321191125212861339137214321472152515781611166417241811184418771938202420662151218522312285234423782411245125052537257726372697273027702824285628902950300330443097315632193248
It412985201104173
allows423285201105386120180268314
for4576852011040100140
a4746852011053
controlled4828852011055114174207247307341374428487
course8511010011053113173213259313
of11931010011060100
the1323101001103393147
disease1499101001106194141194248294347
and18761010011054114174
reduces2081101001104093152212265318364
the2475101001103494148
spread26531010011047107147200253313
of29961010011060100
HIV31261010011087127214
in3369101001103393
the3492101001103494147
population.36691010011060120180240273327360393453513543
The8511269011073133187
principles10671269011060100133193247279339373426473
of15701269011060100
ART17001269011086166239
are1969126901105594148
voluntariness,21471269011060120153213273306360399433493546592639669
timeliness2846126901103367160214247280340394440487
(as3363126901104093139
early35321269011055108148181242
as38021269011054101
possible),39331269011060120166213247307340394433463
continuity44261269011053114174207240301361394427489
(lifelong4941126901104074107147201234294354415
use8511428011060107160
of10411428011060100
the1171142801103393146
drug).13471428011060100160220259289
In851168701104098
clinical979168701105588121181215268321354
practice,13631687011060100153207240273327380409
518021687011060
groups18921687011061100160221281327
of22491687011060100
ARVs23791687011087167253300
are2709168701105393146
used:28841687011060107161221254
1.1031194501106090
Nucleoside12111945011080140194226280340386420480533
reverse17741945011046100153205252298353
transcriptase2156194501103480140200247301347380440474534581634
inhibitors2820194501103393153186247280314374421467
(NRTIs).33191945011040127206280320365406436
They37851945011073133186248
are4060194501105494147
modified42371945011093153213246287320373433
nucleoside/nucleotide121121050110601201732062593193663994595135466066667197528068658999329921046
molecules22862105011093155188241295354387441487
that2803210501103494147180
integrate3013210501103394127180241280333366419
into3462210501103393127188
the3680210501103393147
synthesized38572105011046107165198258312358392445499558
DNA44452105011087174260
chain47352105011054115168201261
and50282105011053113173
stop5231210501104680140200
its1211226301103367114
further13552263011040100140172232286326
assembly.17102263011053100146200293353386449476
2.1031242201106090
Non-nucleoside12112422011080140200240300360413446499559606639699753
reverse19932422011047100153207253300353
transcriptase2376242201103481141201248301348381441475535582635
inhibitors3041242201103393153186247280313374420467
(NNRTIs).35402422011040125212291365406450491521
They40912422011073133186248
block4366242201106094154207267
the4662242201103393148
reverse4840242201104093153206246293346
transcriptase1211258001103373127186233286326359419452506552605
of18462580011060101
the1977258001103393146
virus.2153258001106093133193240270
3.1031273901106090
Protease12112738011073120180213267327373427
inhibitors1667273801103393153187247280314374421468
(PI).21652739011040107148185215
They24112739011073133186247
block2685273901106094154208268
the2983273901103393147
assembly3160273901105399145199292352385448
of36372739011060100
new37672739011060113199
viruses.3996273901106093133193239293339369
4.1031289801106090
Fusion12112898011073133180213273333
inhibitors1574289801103494154187247281315375421468
and20722898011060120180
CCR522822898011080159233293
chemokine26052898011053113166252312365398458511
receptor31462898011047101154207266300360406
inhibitors.3582289801103595155190250283317377424471501
They41132898011073133187247
affect4386289801105594134188241274
the4690289801103393148
receptors4867289801104093146200259293353393439
used12113057011060107160220
by14613057011060121
the1609305701103494148
virus1787305701106093133193240
to2057305701103393
enter21803057011053113147200240
the2450305701103494147
host26273057011060120167200
cell28573057011053106139172
with30603057011086120153213
HIV.33033057011087128213243
5.1031321501106090
Integrase1211321501104098132185246286339385438
inhibitors.1679321501103393153187247280314374414461491
It2200321501104072
blocks2302321501106094155208268315
the2647321501103393147
incorporation2823321501103393147207247306366406460493526587647
of35003215011060100
proviral36303215011060100160220253293347379
DNA40393215011087174260
into4329321501103393126187
human45463215011060120213266327
DNA49033215011087174260
using51933215011060106140200260
the1211337301103393147
virus1388337301106093133193239
integrase1657337301103494127181241279333379433
enzyme.21193373011055114167229321375405
Initiation851363301104098132165199252285319379439
of13203633011060100
ART14503633011086166240
should17203633011046106166226260320
be20703633011061114
recommended2214363301104093146205299392446505565619679
regardless2923363301104094154207246306339394440487
of3440363301106099
CD4+35693633011081169229296
levels3895363301103386146200232279
and42043633011055114174
viral4408363301106095135188221
load,4659363301103393147206236
as49253633011053100
this5055363301103393126173
therapy851379101103393147187239299361
reduces1240379101104094153213266319365
systemic16353791011047110154187241334367421
inflammation2087379101103393133166219312406459492526586646
and27633791011053113173
reduces2966379101104093152212266319366
the3362379101103393146
risk3538379101104073120180
of37483791011060100
developing38783791011060113173227260320380413474534
opportunistic44413791011060120180240280313373433467514547580634
diseases.851395001106093140193247293346392422
ART8514209011087167240
should11214209011047107167227260320
be14714209011060114
postponed16144209011060120167200260320380434493
only21374209011060120154215
if:2379420901103474107
-8514468011040
the921446801103393146
patient's10974468011060114146180233293326349394
serious15214468011047100140173233293340
condition18914468011053113173234267301334394454
requiring2375446801104094153213246286320380440
stabilization2844446801104680133193226260293347401434467527587
of34614468011060100
vital3591446801106093127180213
functions,38344468011040100160213246280340400447477
urgent43414468011060100160213272305
etiotropic4676446801105487120180214254316376409462
treatment851462601103373127179212306359419452
of13334626011060100
secondary14634626011047100154213273333387426488
or19794626011060101
concomitant21104626011053112172225285378412445499559592
diseases2732462601106093140194246293346392
(tuberculosis,3154462601104175135195248287341400433493540573620650
CNS38344626011080167234
damage,40984626011060113207260321374403
etc.)4531462601105487140170210
-8514884011040
the921488401103393146
presence10974884011060100153199252312366419
of15464884011060101
a16774884011053
high1759488401106094155214
risk2003488401104073121181
of22144884011060100
fatal2344488401104092125178212
complications25864884011053113206266299333386440472506566626673
of32894884011061101
ART34204884011086166239
due36894884011060120174
to3892488401103393
the4015488401103494147
development41924884011060113173226259319380474527587620
of48424884011060100
a49724884011053
lifethreatening5055488401103366107160851504401103393133187239272325385419479540
inflammatory1420504401103393133166220313406460493553592655
syndrome21035044011047108166226266326419473
of26055044011060101
immune27365044011033127220280340394
system31595044011047108153187240333
restoration.3522504401104094140173233273326359392453513543
In851530201104098
patients9795302011060115148181235294328374
over13835302011060120174214
5016275302011060120
years17775302011061112166206252
of20595302011061101
age,21905302011053114166195
it2415530201103467
is2512530201103480
possible26225302011060120167214247308341394
to3046530201103494
consider31705302011053113173219253313366406
the3606530201103393146
initiation3782530201103393126160193247280313374434
of42465302011060100
ART43755302011087167240
as46455302011054100
a47755302011053
priority48585302011060100133193233266299361
due52465302011060120175
to851546001103393
the974546001103494147
risk1151546001104073120180
of13615460011060100
a14905460011054
more15735460011094154194247
rapid1849546001104094154187248
development21275460011060114173227259319379473526586619
of27765460011060100
the2906546001103494147
disease.3083546001106093140194247293347376
If3489546001104180
an35995460011054113
HIV-infected37425460011087129214255288348388442495528581641
pregnant44135460011061101154214273327386419
woman48625460011087147240294354
is5246546001103380
detected8515620011060113146199253285339399
at1280562001105487
a13975620011053
gestation14805620011061113159192246279312372432
period19425620011060114155188248308
of22805620011060100
2824095620011060120
weeks25595620011087140193252299
or28885620011060101
more,30195620011094154194246277
ART33265620011087167240
should35965620011047107167227260320
be39465620011060114
started4089562001104780133173206260320
no44395620011060120
later4591562001103387120173213
than4834562001103393146206
350705620011060
days,51605620011060113175219249
regardless851577901104093153206245305338393439486
of1367577901106099
the1496577901103494147
indications1673577901103393153187240293326359421481528
of2231577901106099
viral2360577901106094134187220
load.2610577901103393147206236
Table8516038011073127186219273
1.1154603801106090
Indications1274603801104099159192246300333366426486533
for18376038011040100140
the2006603801103494147
rapid2183603801104093152185245
onset24586038011060120167221253
of27416038011060100
ATR28726038011087160240
in3142603801103494
children.32666038011053113146180240280333392422
Criteria8516304010887140173213266318351411
Indications24466304010847114181214268328368400460527574
Age8516442011087147200
under24466442011060120180233273
127496442011060
year28396442011062113165206
old3075644201106093153
Clinical8516586011080114147207241294347380
manifestations12616586011093147206240280333379412466499532592652699
stages2446658601104780133193245291
2B27676586011060142
4Б29386586011060130
4В30986586011060140
according32676586011054107160220261321354415475
to3771658601103393
the3894658601103394147
Russian40716586011080140187233267320380
qualification44816586011060120173206239280313366420453486547607
Level8516729011073125185239272
CD4,11536729011080167227257
cell/cub1440672901105410613917220616476729011053113173
mm18506729011093187
124466729011060
year25366729011061112166205
-27716729011040
528416729011060
years29316729011062113167206253
≤40416729011066
50041376729011060120180
624466872011060
years25366872011061112166205252
and28186872011053113173
older3021687201106093153208247
≤40416872011066
20041376872011060120180