261
1954097556011060120
1.120559201106090
Binding1385592011080113173233266326386
of1800592011060101
the193159201103393147
virion210759201106094133167227287
to242459201103393
the254759201103494147
cell2724592011053106139172
surface,2927592011046106146186240293345375
fusion3332592011041101148181241301
of3663592011060100
virion379359201106194134167227287
and4110592011054113173
cell4313592011054106139173
membranes.4516592011093147240300340393452507553583
2.120580001106090
The1385800011073133187
virus1601800011089122162222269
penetrates1900800011088142201254287327381413468514
into2444800011062122156216
the2690800011062122175
cell,2895800011082135168201231
with31568000110116149182242
the3428800011063123176
participation3634800011088142181215248301334394448481514574634
of4298800011089129
reverse4457800011068122181234274320374
transcriptase,4860800011062102156217263317356390450483536583636665
information1385100701103393133193233326379413446506566
from1981100701104080140233
viral2244100701106093134187219
RNA24931007011080169255
is2778100701103380
rewritten2888100701104093179219252285319372432
into3350100701103494127187
DNA.35671007011087173261291
3.1205121401106090
Integration1385121401104098132185246286339372405465525
of19401214011060100
the2070121401103393147
virus2247121401106093133193239
genome25171214011061114174234327381
into2928121401103393126186
the3144121401103494147
genome33211214011060113173233326379
of37301214011060101
an38611214011053112
infected4003121401103494134187241274327387
cell.44201214011053107140173203
4.1205142101106090
Activation13851421011087140173206266320352386446506
of19211421011071111
transcription2062142101104383137196243296336369429462496556616
from2708142101105191150243
provirus29811421011071111171231264304364411
DNA34321421011087174260
and37221421011064123183
subsequent39351421011057117177224277337397451510543
transcription4508142101104585138197244297337370430464497557617
of51551421011071111
viral52961421011070103143197229
proteins.13851628011060100160193247279339386416
5.1205183501106090
The13851835011073133187
development16011835011060113173226259319379472526585619
of22501835011060100
all2380183501105487120
components25311835011053114207267327387440500534580
of31411835011060100
the3271183501103494147
virus3447183501106094134194240
with37171835011087121155215
the3962183501103393147
formation4139183501103999139232285318352412472
of46411835011060100
new47711835011060113199
virions.5000183501106194134168228288334364
6.1205204201106090
The13852042011073133187
release1601204201104093126179233279333
of19632042011060100
the2093204201103494148
virus2270204201106094134194240
from2540204201104081141234
the2804204201103494147
cell,29812042011053106139173203
resulting3214204201104093139199232266300360421
in3664204201103393
the3787204201103394147
death39642042011060113166199259
of42532042011060100
the4383204201103393146
target4559204201103487127188240273
cell.48622042011053107140174204
From12052249011067106166259
the1494224901103797150
moment16782249011093153246300359393
the2101224901103797150
virus2282224901106397137198244
genome25562249011064117177237330383
is2969224901103784
embedded30832249011057150210263323383437497
into3610224901103898131191
the3831224901103797151
cell40122249011056109142175
genome,42172249011065117177237330383413
the4660224901103797152
latent4842224901103790124177236270
stage5142224901105084137198250
of54212249011064105
infection1205245701103393133187239272306366426
begins.16612457011092145206238298345375
HIV206624570110120161246
gene23422457011093146205259
expression26312457011087146207247301346393426487547
will320824570110119152185219
be34572457011092146
triggered36322457011066106139200260312352406465
by41272457011093155
factors43102457011073126180213273313359
that46992457011066127181214
activate49432457011085138171204265318351404
Tlymphocytes5378245701101061205266301103395186246306366419481512565612
(specific18472663011094140200254307340380413467
and234326630110109168228
non-specific260126630110114174234275321381435488520560594648
antigens,327926630110107166200233295347407454484
cytokines,379326630110107168199259319352413466512542
bacterial436526630110114168221254307347380435468
modulators),486326630110147207267327360414447507547594634664
glucocorticoid1205287101106092152206265320379419452486539599632692
hormones,19272871011091151191285345405458504535
ultraviolet24922871011092125159199252312345405438492525
irradiation,30472871011064104144197257290343377410470530561
hydrogen36382871011091152210250310370424483
peroxide,41512871011091144184244304338398451481
and46622871011084144204
free48962871011071111164216
oxygen51422871011091151213271324385
radicals.1205307701104093152186239292325372402
Immunopathogenetically,12053285011040132225285345405465519552612672733785845899932965101910721104113812011229
HIV24653285011087128213
is2708328501103481
characterized28193285011055114167207261314347400440473526580639
by34883285011062124
a36413285011054
deficiency37253285011061114153187240273326386440502
of42543285011060101
the4385328501103595148
T45643285011073
and46673285011054114175
B48733285011080
links4982328501103568128188235
of52473285011061101
the5378328501103494147
immune12053491011033127220280340394
system,16293491011053114158191244338368
a20273491011060
deficiency21173491011067120160194247280334394447509
of26523491011068109
complement,27913491011060119212272306359452506566599629
phagocytes,34503491011067127180240299353415446499546576
and40563491011060119179
a42653491011061
decrease43553491011067121174214267320366420
in48063491011041101
the49373491011040100157
function51243491011047107167220253286346406
of12053699011060100
nonspecific13353699011062122182229289342395428468501555
protective19203699011062102162196250303335369429482
factors.2433369901104296148181241282329359
The28243699011073133187
p1530413699011062122182
virus3253369901106396136196243
protein35273699011062102163196249283343
suppresses39003699011049109169229269322368414468514
the4444369901103696151
production46243699011062102162222283336369403463523
of51773699011062102
IL-253093699011043117158219
and12053905011053113173
γ-interferon1408390501105393126186219273312353406445505565
by20033905011060122
T21543905011073
cells.22573905011053106139172220250
Antiviral,25373905011087147180214274307347401433463
antibacterial30303905011054114147180240294347380433473506560593
and36533905011053113173
antitumor38563905011054113146180213273367427467
protection43533905011060100159193246299332365426486
of48693905011061101
the5000390501103393146
body51763905011060120180242
is5446390501103380
associated1205411301105399146206259293346379432492
with172741130110137170204264
the20214113011084144197
production224941130110110150211271331384417450510570
of284941130110111151
IL-230304113011091164204263
(and33254113011090143202262
other361841130110111144204257297
cytokines).394541130110103165196256316349410463509550581
This455641130110124184217265
explains485141130110104163224258311344404451
the53324113011084144197
development12054319011060113173226259319379472526585619
of185443190110118158
various204243190110117170209243303363410
secondary248243190110105158211270330390444483545
diseases:305543190110117151197250304350404451484
opportunistic356943190110118178238298338371431491524571604638692
infections,42904319011091151191244297330363423483530560
oncological,488043190110118178231291324384444476530583615645
hematogenic,12054527011060113206259293353413466526559612642
autoimmune,18774527011054113146206240333427487547600630
and25374527011053113173
lymphoproliferative.2740452701103395185245305365425466526560593633686726780813846906960989
The12054733011073133187
number14214733011077137230290343383
of18344733011076116
colony-forming19804733011070129163223283345384423484524617651711771
granulocytes,27804733011077116170229289322382435497528583629659
macrophages,346947330110110164217256316376436489550603649679
and41784733011070130190
megakaryocytes439847330110110163224276335390430491549603665695749795
in52234733011051111
the53644733011050110163
bone12054941011060120180233
marrow146849410110142196235275335422
decreases192049410110109162215256309361408462508
sharply.24594941011097157211250310344406433
Suppression292249410110116177237297337390436482516576636
of358849410110110150
hematopoiesis376849410110109162255308342402462522555608655688735
is45334941011083130
associated469349410110102148196256310343396429482542
with526549410110136169202262
increased1205514701103393147187239292338393452
production168751470110118158218278338391424457517577
of229451470110118158
tumor24825147011090150244304344
necrosis285651470110117170223263323369403449
factor33355147011098151204236296336
by370151470110118179
bone390651470110118178238292
marrow422851470110150204244283343430
monocytes468751470110151212272332385446477532578
and529551470110111170230
macrophages.12055355011093147200239299359419472533586632662
Clinically,189753550110194228261322355408461494527588615
this254353550110148208241288
is286153550110147194
manifested308553550110208261321354394447493527580640
by375553550110174235
leukopenia,401853550110147200260320380440494554587640670
anemia,471853550110168228281374408461491
and523953550110167226286
thrombocytopenia.1205556101103393133193287347407460521552612672725785818873902