Вид документа : Статья из журнала Шифр издания : Автор(ы) : Поляковский К. А., Глухов А. И., Зезеров Е. Г., Варшавский В. А., Винаров А. З., Амосов А. В., Рапопорт Л. М., Аляев Ю. Г., Северин Е. С., Зимник О. В. Заглавие : Простатспецифический антиген и теломераза при онкологических заболеваниях предстательной железы Место публикации : Клиническая лабораторная диагностика. - 2008. - № 12. - С.37-38 (Шифр К4/2008/12) Примечания : Библиогр.: с. 38 (16 назв.) ГРНТИ : 76.35.33 + 76.29.43 + 76.29.49 MeSH-главная: Предстательной железы специфический антиген -- Prostate-Specific Antigen Теломераза -- Telomerase MeSH-неглавная: Аннотация: A correlation between the blood level of prostate-specific antigen (PSA) and the prostatic tissue activity of telomerase was analyzed in prostate cancer (PC), low- and high-grade prostatic intraepithelial neoplasia (LG PIN, HG PIN) and in benign prostatic hyperplasia (BPH). The study was based on the results of a comprehensive examination of 92 patients from the Clinic of Urology, I. M. Sechenov Moscow Medical Academy. 44% of the patients were diagnosed as having PC; 49% had LG PIN and BPH; 7% had HG PIN and BPH. Active telomerase in the prostate biopsy specimens was found in 98% of the patients with PC, in 33% of those with HG PIN, and in 20% of those with LG PIN. When active telomerase was detected in the prostate biopsy specimens of patients with urological cancer (PC, PIN, BPH, the blood content of total PSA) was statistically significantly higher than that in the absence of this enzyme Держатели документа: ОмГМУ : 644099, г. Омск, ул. Ленина, 12 Доп.точки доступа: Поляковский, К. А. Глухов, А. И. Зезеров, Е. Г. Варшавский, В. А. Винаров, А. З. Амосов, А. В. Рапопорт, Л. М. Аляев, Ю. Г. Северин, Е. С. Зимник, О. В.